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Rabbit Anti-twist Polyclonal Antibody#abs131319

Kindly note that the price mentioned above is only for your reference. For detailed information on the pricing, please reach out to our seller Vecent. Western blot analysis of twist expression in Jurkat cells This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs131319-100ug	1-2 Weeks	301.0
abs131319-50ug	1-2 Weeks	201.0

Kindly note that the price mentioned above is only for your reference. For detailed information on the pricing, please reach out to our seller Vecent.

Overview
catalog	abs131319
Description	Sequestering E proteins, inhibiting trans-activation by MEF2, and blocking DNA-binding by MYOD1 via physical interaction, this molecule functions as a transcriptional regulator. Its inhibitory role leads to the repression of myogenesis, as well as the suppression of proinflammatory cytokines like TNFA and IL1B. The interaction between this molecule and its targets likely involves the basic domains of both proteins.
Other names	TWIST1 is a DNA binding protein classified as a basic helix-loop-helix (bHLH) transcription factor. It is also known as bHLHa38 and has various other aliases such as BPES2, BPES3, CRS, CRS1, CSO, H-twist, OTTHUMP00000116043, SCS, Twist basic helix loop helix transcription factor 1, and Twist family bHLH transcription factor 1. TWIST1 is the human homolog of the Twist gene found in Drosophila. It is involved in the regulation of cell differentiation and development. Mutations in TWIST1 have been associated with certain genetic disorders, including Branchio-oculo-facial syndrome 2 (BPES2) and Setleis syndrome (BPES3). The protein encoded by TWIST1 is important for embryonic development, particularly in the formation of organs and tissues derived from the mesoderm and ectoderm. It plays a crucial role in processes like craniofacial development and limb patterning. TWIST1 is known to regulate the expression of several genes involved in cell growth and differentiation, including those that play a role in epithelial-mesenchymal transition (EMT). EMT is a process where epithelial cells acquire mesenchymal characteristics and is important in various biological processes, such as embryogenesis and cancer metastasis. Abnormal expression and function of TWIST1 have been implicated in various cancers, including breast, lung, and prostate cancer. TWIST1 promotes tumor progression by enhancing cell migration, invasion, and metastasis. It is also involved in the regulation of cancer stem cell properties and drug resistance. In summary, TWIST1 is a transcription factor that plays a crucial role in embryonic development and is involved in various cellular processes. Its dysregulation is associated with genetic disorders and cancer progression. Understanding the molecular mechanisms underlying TWIST1 function may provide novel insights into development and disease pathogenesis.
Source	Rabbit
Specificity	The endogenous levels of total twist can be detected using the twist Antibody. The content can be further paraphrased as the twist Antibody is capable of identifying the total twist present within an organism's system.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Bovine
Antigen	twist
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human twist.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be generated by rearranging this information, which indicates that the antiserum was subjected to a purification process that involved peptide affinity chromatography using SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
Tissue specificity	Subset of mesodermal cells.
Celluar localization	Nucleus;
UniPort	Q15672