Rabbit Anti-Elastin Polyclonal Antibody#abs131321
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Description
| Catalog-specification | Delivery time | USD price |
abs131321-50ug | 1-2 Weeks | 201.0 |
abs131321-100ug | 1-2 Weeks | 301.0 |
Dear Customers, please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative Vecent. We urge you to reach out to us for all your queries and concerns. Our team is always ready to assist you in any way we can. Thank you for considering our products and we look forward to hearing from you soon.
| Overview | |
catalog | abs131321 |
Description | The principal component of tissues such as the aorta and nuchal ligament is a vital structural protein that necessitates swift expansion and full recuperation. This protein is the driving force behind the final arterial morphogenesis, stabilizing the arterial arrangement by managing the organization and proliferation of the vascular smooth muscle. |
| Other names | Tropoelastin is also known as elastin and is coded for by the ELN gene. In humans, the ELN gene is known to be associated with Williams-Beuren syndrome (WBS) and Supravalvular Aortic Stenosis (SVAS). ELN_HUMAN is the gene ID for the human version of elastin. The protein elastin, which is produced by this gene, is responsible for the elasticity of many body tissues. It provides flexibility to several organs such as lungs, skin, and blood vessels and is crucial to the proper functioning of these organs. The expression of elastin is vital in various disease conditions related to exocrine gland function, inflammation, and tissue damage, making it a significant target for research in the biomedical field. |
| Source | Rabbit |
| Specificity | The Elastin Antibody is specifically designed to detect the total amount of Elastin present in an organism. It detects the endogenous levels of Elastin which helps to identify the presence of any deformities or mutations related to the protein. The antibody is a reliable tool in the field of molecular biology and is widely used for research purposes. Its ability to detect Elastin levels with high accuracy makes it an essential component in numerous scientific experiments. |
| Species Reactivity | Human;Mouse |
| Antigen | Elastin |
| Application | WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide derived from human Elastin. |
| MW | 68 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was isolated through peptide affinity chromatography. A highly purified form of the antiserum was obtained through this process. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain the stability of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freezing and thawing cycles, as this can negatively affect its quality. Therefore, it is essential to handle and store the product with care to ensure its efficacy and potency. |
| Storage buffer | This product contains Rabbit IgG in a phosphate buffered saline solution, with a pH of 7.4 and 150mM NaCl. It contains a small amount of sodium azide (0.02%) as a preservative and 50% glycerol as a cryoprotectant. For optimal preservation, store at a temperature of -20 °C. This product is stable for up to 12 months from the date of receiving. |
Target | |
Background | Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). |
| Tissue specificity | Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin. |
| Posttranslational modification | Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. |
| Celluar localization | Extracellular region or secreted; |
| UniPort | P15502 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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