CSRNP1 Polyclonal Antibody #abs117683

abs117683-50ul

In Stock

228

Other names

AXUD1;CSRNP-1;FAM130B;TAIP-3;URAX1

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100

Immunogen

，CSRNP1（NP_149016.2）1-200。，。

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
，：pH7.3PBS，0.02％，50％。

Target

Background

Elevated levels of axin trigger the induction of a specific gene, which encodes a protein that localizes to the nucleus. This gene plays a crucial role in the Wnt signaling pathway, which is negatively regulated by axin. During early development, the Wnt signaling pathway is vital for axis formation. However, disruptions in the regulation of this pathway are often observed in tumors.
Interestingly, tumor cells typically exhibit a reduced expression of this gene compared to their corresponding normal tissues. This suggests that the product of this gene functions as a tumor suppressor. It exerts its suppressive effects by modulating the activity of the Wnt signaling pathway, preventing aberrant cell growth and proliferation.
It is worth noting that alternative splicing of this gene leads to the production of multiple transcript variants. This expands the diversity of the gene's products and may contribute to its multifaceted functions in various cellular contexts.

Celluar localization

Nucleus

UniPort

Q96S65