PTEN Polyclonal Antibody #abs115987

abs115987-50ul

In Stock

228

Other names

10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;PTENbeta;TEP1

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

IHC 1:50 - 1:200
IF 1:50 - 1:200

Immunogen

Recombinant protein of human PTEN

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
A buffer solution called PBS containing 0.02% sodium azide and 50% glycerol was prepared at a pH of 7.3. This concoction has a high similarity to the original content, but the information has been rearranged to avoid directly copying the original text.

Target

Background

This particular gene has been identified as a frequent target for mutations in various cancers, making it a crucial tumor suppressor. The encoded protein serves as a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and possesses both a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases. Unlike typical protein tyrosine phosphatases, this protein exhibits a preference for dephosphorylating phosphoinositide substrates. Its primary function involves the negative regulation of phosphatidylinositol-3,4,5-trisphosphate levels within cells, thereby acting as a tumor suppressor by exerting a negative influence on the AKT/PKB signaling pathway. Interestingly, an alternative translation start site, marked by a non-canonical (CUG) codon, generates a longer isoform that commences with a leucine amino acid. This isoform is believed to have a specific association with the inner membrane of mitochondria and potentially contributes to the regulation of energy metabolism within these organelles. Additionally, a pseudogene of this gene can be found on chromosome 9. Due to alternative splicing and the utilization of multiple translation start codons, different isoforms are produced, resulting in various transcript variants.

Celluar localization

Cytoplasm,Nucleus,PML body,Secreted

UniPort

P60484