UBXN6 Antibody (C-term) #abs107720

abs107720-50ul

In Stock

228

Description

A highly specific Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) can be acquired for advanced research purposes. This antibody is generated using a peptide with excellent recognition properties, making it a reliable tool for use in a wide range of applications. Its high-binding affinity and superior specificity also make it suitable for numerous downstream assays, including ELISAs, Western blotting, and immunohistochemistry. The rabbit polyclonal antibody has a robust and versatile structure, making it ideal for many research applications. Furthermore, the antibody purification process guarantees batch-to-batch consistency and improved sensitivity, ensuring reliable and consistent results for your research.

Other names

There are several proteins that have UBX domains, including UBX domain-containing protein 6, UBX domain-containing protein 1, UBXD1, and UBXDC2. These proteins are involved in various cellular processes, such as protein degradation and membrane trafficking.
Among these proteins, UBX domain-containing protein 6 (UBXN6) plays a crucial role in the regulation of autophagy. Autophagy is a process by which cells break down and recycle their own components. UBXN6 acts as a regulator of autophagy by interacting with key proteins involved in this process.
On the other hand, UBX domain-containing protein 1 (UBXD1) is involved in the regulation of endoplasmic reticulum-associated protein degradation (ERAD). ERAD is a quality control mechanism that removes misfolded or damaged proteins from the endoplasmic reticulum. UBXD1 is believed to be a key player in this process by mediating the interaction between ubiquitinated substrates and the proteasome.
Lastly, UBXDC2 is another UBX domain-containing protein that has been linked to the regulation of autophagy. Recent studies suggest that UBXDC2 may play a role in the formation and maturation of autophagic structures, such as autophagosomes.
In summary, UBX domain-containing proteins are a diverse group of proteins that play important roles in various cellular processes. Understanding their functions and interactions could provide valuable insights into the underlying mechanisms of these processes.

Source

Rabbit

Specificity

The UBXN6 antibody, derived from rabbits immunized with a synthetic peptide conjugated to KLH, specifically targets the C-terminal region of human UBXN6 comprising amino acids 281-309. Let me rephrase that content for you, ensuring it maintains the original information but presented differently.

Species Reactivity

Human;Mouse

Predictive reaction species

B

Application

WB~~1:1000
IHC-P~~1:50~100

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To ensure the quality of this product, it is recommended to store it in the refrigerator between 2-8°C for a maximum of two weeks. To extend the shelf life, it is best to store it at -20°C, but make sure to split it into smaller portions to prevent damage caused by repeated freeze-thaw cycles.

Storage buffer

This antibody is provided in a purified form, as a polyclonal antibody with a sodium azide concentration of 0.09% (W/V), dissolved in PBS. The purification process involves the use of a protein A column, followed by a peptide affinity purification step. This ensures that the antibodies are highly specific and free from any impurities that may interfere with their activity.

Research area

Cell Biology

Target

Background

Cooperating with USP7, this complex participates in the promotion of MDM2 deubiquitination and stabilization, ultimately resulting in the degradation of TP53 through MDM2-dependent mechanisms. VCP forms an intricate relationship within this process, facilitating the stability of MDM2. Utilizing this coaction, the complex orchestrates the intricate balance necessary for MDM2-dependent TP53 degradation.

Celluar localization

The centrosome is where this protein localizes, both in interphase and during mitosis. In addition, it can be found in the cytoplasm, cytoskeleton and microtubule organizing center. It also has a presence in the nucleus.

UniPort

Q9BZV1

References

References

Nagahama, M., et al. Biochem. Biophys. Res. Commun. 382(2):303-308(2009)
Kern, M., et al. Biochem. Biophys. Res. Commun. 380(2):303-307(2009)
Madsen, L., et al. Int. J. Biochem. Cell Biol. 40(12):2927-2942(2008)