HSD17B1 Antibody (C-term) #abs102796

abs102796-50ul

In Stock

228

Description

Our company offers a Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) that is of high quality. We ensure that our Pab is highly similar to the original peptide through our purification process, which involves using antibodies raised in rabbits. Our Pab guarantees efficient and accurate detection of the peptide.

Other names

17-beta-dehydrogenase 1, also known as estradiol 17-beta-dehydrogenase, is an enzyme responsible for the conversion of estradiol to estrone. It is also referred to as 17-beta-hydroxysteroid dehydrogenase type 1 or 17-beta-HSD 1. Another name for this enzyme is 20 alpha-hydroxysteroid dehydrogenase or 20-alpha-HSD. It is sometimes called E2DH or placental 17-beta-hydroxysteroid dehydrogenase.
HSD17B1, or 17-beta-dehydrogenase 1, plays a crucial role in the metabolism of estrogen hormones. It catalyzes the conversion of estradiol, the most potent estrogen, into estrone, which is less active. This enzyme is found in various tissues, including the placenta, where it is involved in regulating estrogen levels during pregnancy.
Known by different aliases such as E17KSR, EDH17B1, EDH17B2, and EDHB17, HSD17B1 is essential for maintaining the balance of estrogens in the body. Alterations in its activity can lead to hormonal imbalances and contribute to diseases such as breast and prostate cancer.
Understanding the functions and characteristics of HSD17B1 allows for a better comprehension of estrogen metabolism and its implications in health and disease. Ongoing research aims to explore the potential of targeting this enzyme for therapeutic purposes in hormone-related conditions.

Source

Rabbit

Specificity

The antibody against HSD17B1 is produced by immunizing rabbits with a synthetic peptide that is conjugated to KLH. The peptide is located within the C-terminal region of human HSD17B1 and contains amino acids 227-256. To create similar content based on this information, one could say that the HSD17B1 antibody was obtained through rabbit immunization with a synthetic peptide that is attached to KLH. The peptide used is derived from the C-terminal region of human HSD17B1 and consists of amino acids 227-256.

Species Reactivity

Human

Application

WB~~1:1000

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To keep the product fresh, it is recommended to store it in a refrigerated environment between 2 and 8°C for a maximum of 2 weeks. If you need to keep it for a longer period, it is recommended to store it at -20°C in small aliquots, so that you can avoid any potential freeze-thaw cycles. By taking care to store the product correctly, you can be assured that it will retain its quality and effectiveness in the long term.

Storage buffer

This polyclonal antibody is provided in PBS with 0.09% (W/V) sodium azide and has undergone purification using a protein A column, followed by peptide affinity purification.

Research area

Cancer;Metabolism;Neuroscience;Signal Transduction

Target

Background

The reduction of estrogens and androgens is strongly favored by this compound, which also possesses 20-alpha-HSD activity. Moreover, it demonstrates a preference for using NADH as a coenzyme.

Celluar localization

Cytoplasm.

UniPort

P14061

References

References

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press :
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)