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Rabbit Anti-TYK2 Polyclonal Antibody#abs131318

Description

Catalog-specification	Delivery time	USD price
abs131318-50ug	1-2 Weeks	201.0
abs131318-100ug	1-2 Weeks	301.0

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Overview
catalog	abs131318
Description	It is speculated that this protein participates in intracellular signal transduction by initiating type I interferon (IFN) signaling. One of its functions is to phosphorylate the alpha chain of the IFN-alpha/beta receptor, which plays a crucial role in mediating type I IFN-induced biological responses.
Other names	JTK1, also known as non-receptor tyrosine protein kinase 2 or TYK2, is a protein tyrosine kinase that is involved in various cellular processes. It plays a crucial role in the immune system by regulating cytokine signaling pathways and activating transcription factors. TYK2 has also been implicated in the development of autoimmune diseases and cancer. OTTHUMP00000232745, OTTHUMP00000232746, and OTTHUMP00000232748 are alternative identifiers for the TYK2 gene. Understanding the function of TYK2 and its signaling pathways is essential for the development of new therapies for various diseases. Overall, TYK2 is an important protein with diverse functions in the body.
Source	Rabbit
Specificity	Detection of total TYK2 is achieved using the TYK2 Antibody, which has the capability to identify the endogenous levels of the protein. By utilizing this antibody, one can accurately determine the presence and quantity of TYK2 in biological samples.
Species Reactivity	Human
Predictive reaction species	Xenopus;Dog;Horse
Antigen	TYK2
Application	My recommended dilutions for Western Blot (WB) range from 1:500 to 1:2000. For Immunofluorescence (IF) and Immunocytochemistry (ICC), I suggest dilutions between 1:100 and 1:500. When performing ELISA (peptide), the recommended dilutions are 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human TYK2.
MW	134 kDa.
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Tissue specificity	Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	P29597