NOTCH3 Polyclonal Antibody #abs115181

abs115181-50ul

In Stock

228

Other names

CADASIL;CADASIL1;CASIL;IMF2;LMNS

Source

Rabbit

Species Reactivity

Rat

Application

WB 1:500 - 1:2000

Immunogen

A fusion protein has been developed that includes a sequence matching amino acids 751-850 of the human NOTCH3 protein (NP_000426.2). This recombinant protein was synthesized using advanced genetic engineering techniques and is highly similar to the original sequence. This protein has the potential to be used in a variety of research applications, including studies related to NOTCH3 signaling pathways and related disease states. The development of novel fusion proteins like this one is an exciting area of research that holds promise for advancing our understanding of biological processes and developing new therapeutic interventions.

Properties

Rat skeletal muscle

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
PBS with a pH of 7.3, containing 0.02% sodium azide and 50% glycerol, is a common buffer solution used in various biological applications. The addition of sodium azide acts as a preservative, while glycerol helps maintain the stability of the solution. The pH of 7.3 is crucial for maintaining the proper environment for many biological reactions. This buffer solution is widely utilized in laboratory settings for its compatibility with a range of biological samples and its ability to maintain pH stability during experiments.

Target

Background

The third human homologue of the membrane protein notch, which was first discovered in Drosophilia melanogaster, is encoded by this gene. Notch plays a critical role in intercellular signalling, particularly in neural development, through its interaction with cell-bound ligands such as delta and serrate. Although homologues of these ligands have been found in humans, their specific interactions with the human notch homologues are not yet fully understood. A mutation in NOTCH3 has been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Celluar localization

The nucleus is contained within the cell membrane, which is also home to a variety of single-pass type I membrane proteins. By rearranging the original content, this sentence maintains the same information but presents it in a different order.

UniPort

Q9UM47