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Rabbit Anti-TGFBR2 Polyclonal Antibody#abs131552

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent. Western blot analysis of TGFBR2 expression in HeLa cells This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs131552-50ug	1-2 Weeks	201.0
abs131552-100ug	1-2 Weeks	301.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent.

Overview
catalog	abs131552
Description	TGFB1, TGFB2, and TGFB3 are cytokines that bind to the TGF-beta type I serine/threonine kinase receptor, TGFBR1. This receptor is involved in various physiological and pathological processes by transmitting the signals of TGFB1, TGFB2, and TGFB3 from the cell surface to the cytoplasm. One of its key functions is regulating cell cycle arrest in epithelial and hematopoietic cells. It plays a crucial role in maintaining the balance of these cells and ensuring their proper functioning. Through its interaction with the TGF-beta cytokines, TGFBR1 acts as a non-promiscuous receptor, specifically recognizing TGFB1, TGFB2, and TGFB3. This transmembrane serine/threonine kinase is responsible for mediating the effects of these cytokines, which have a wide range of impacts on cellular processes. Overall, the TGFBR1 receptor is an essential component in the signaling pathway of TGFB1, TGFB2, and TGFB3, contributing to the regulation of numerous biological functions.
Other names	The TGF beta receptor type II, also known as TbetaR-II or TGFR-2, is a vital receptor in the transforming growth factor beta (TGF-beta) signaling pathway, involved in regulating cellular growth, differentiation, and apoptosis. This receptor is encoded by the TGFBR2 gene and is among the numerous receptors that bind and respond to the TGF-beta family of cytokines. Additionally, the TGF beta receptor type II is responsible for mediating the effects of TGF-beta by forming a heteromeric complex with the TGF-beta receptor type I, and consequently phosphorylating the downstream effector proteins, Smad2 and Smad3. Various TGF beta receptor type II isoforms, including TGF beta receptor type IIB and Transforming growth factor beta receptor type IIC, have been identified, each with distinct expression patterns and cellular functions. Apart from these, there are also TGF beta receptor type II alpha, TGF beta receptor type II beta, TGF beta receptor type II delta, TGF beta receptor type II epsilon, and TGF beta receptor type II gamma. All these isoforms are critical in the TGF-beta signaling pathway and play a crucial role in modulating cellular responses to various stimuli. Overall, the TGF beta receptor type II and its various isoforms are essential in several physiological and pathological processes, including organ development, tissue repair, cancer, and fibrosis, among others. Therefore, understanding their roles and signaling mechanisms could provide novel approaches for developing therapeutic strategies targeted at the TGF-beta signaling pathway.
Source	Rabbit
Specificity	The TGFBR2 Antibody is capable of detecting total TGFBR2 levels occurring naturally within the body. By utilizing this antibody, researchers can gain insight into the overall expression of TGFBR2 within biological systems.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Horse;Bovine;
Antigen	TGFBR2
Application	The dilutions for WB range from 1:500 to 1:2000, for IHC they range from 1:50 to 1:200, and for ELISA (peptide) the dilutions range from 1:20000 to 1:40000. It is important to carefully adjust the dilutions to achieve optimal results in these techniques. The suggested dilution ranges provided above are based on the original information.
Immunogen	A synthesized peptide derived from human TGFBR2.
MW	63 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Posttranslational modification	Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P37173