Rabbit Anti-MLANA Polyclonal Antibody #abs130141

abs130141-50ug

1-2 Weeks

201

abs130141-100ug

1-2 Weeks

301

Description

MLANA plays an essential role in the organization, movement, and breakdown of SILV/PMEL17, a protein found in melanocytes that is necessary for the creation of stage II melanosomes. This interaction with SILV/PMEL17 is crucial to maintain the proper expression, stability, trafficking, and processing of the protein. Overall, MLANA serves as a crucial player in the formation of melanosome precursors and the subsequent pigmentation of the skin.

Other names

AA Antigen LB39; AA Antigen LB39-AA; Antigen AA SK29; AA Antigen SK29-AA; HUMAN MAR1; MART 1 Antigen; MART-1; MART1; A Melan; Melan-A Protein; T cells Recognized Melanoma Antigen 1; T-cells Recognized Melanoma Antigen 1; A MLAN; A MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Melan-A Protein.
Rearranging the content gives a list of various antigens and proteins:
- AA Antigen LB39
- AA Antigen LB39-AA
- Antigen AA SK29
- AA Antigen SK29-AA
- HUMAN MAR1
- MART 1 Antigen
- MART-1
- MART1
- A Melan
- Melan-A Protein
- T cells Recognized Melanoma Antigen 1
- T-cells Recognized Melanoma Antigen 1
- A MLAN
- A MLANA
- OTTHUMP00000021036
- OTTHUMP00000021037
- OTTHUMP00000021038
- Melan-A Protein

Source

Rabbit

Specificity

The MLANA antibody is specifically designed to recognize and measure the levels of total MLANA protein naturally present in an organism.

Species Reactivity

Human;Mouse

Application

Western blotting (WB) is typically performed using dilutions of antibodies ranging from 1:500 to 1:3000. Immunohistochemistry (IHC) requires dilutions of antibodies ranging from 1:50 to 1:200. For immunofluorescence/immunocytochemistry (IF/ICC), antibody dilutions of 1:100 to 1:500 are commonly used. When performing ELISA with peptide antigens, antibody dilutions of 1:20000 to 1:40000 are recommended. Please note that the dilution ranges provided are based on the original text information.

Immunogen

A synthesized peptide derived from human MLANA.

Properties

Concentration

1mg/ml

Purification

SulfoLink™ Coupling Resin was employed for the purification of the antiserum through peptide affinity chromatography.

Clonality

Polyclonal Antibody

Stability & Storage

-20°C，，/。

Storage buffer

This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, as well as 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C. It is also important to note that this product is stable for up to 12 months from the date of receipt.

Target

Background

GPR143 stability is critical in melanosome biogenesis, and it is ensured by this protein. Another crucial function of this protein is to regulate the expression, stability, trafficking, and processing of PMEL, a melanocyte protein responsible for the formation of stage II melanosomes. Its involvement in these processes highlights the importance of this protein in melanocyte function and pigmentation.

Tissue specificity

The scope of expression is limited to cell lines of melanoma and melanocytes, as well as the retina. It is important to note that these are the only areas where this particular type of expression has been observed. When analyzing gene expression levels, it is essential to consider the specificity of the tissue or cell type being studied. In this case, a narrow focus allows for a more detailed analysis of the genetics underlying melanoma and the function of melanocytes in the retina.

Posttranslational modification

Acylated.

Celluar localization

Endoplasmic reticulum;Golgi apparatus;Plasma Membrane;

UniPort

Q16655