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Rabbit Anti-MPP1 Polyclonal Antibody#abs137753

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Description

Catalog-specification	Delivery time	USD price
abs137753-50ug	1-2 Weeks	201.0
abs137753-100ug	1-2 Weeks	301.0

Overview
catalog	abs137753
Other names	The 55 kDa erythrocyte membrane protein, also known as EMP55 or palmitoylated membrane protein 1, plays an important role in maintaining the integrity of the red blood cell membrane. It is encoded by the aging associated gene 12 (AAG12) and migration related gene 1 (MRG1) on the DXS552E locus. Additionally, the protein is post-translationally modified through palmitoylation to aid in its stability and localization within the membrane. Dysfunction or loss of EMP55 can lead to Red Blood Cell Hemolysis and other related disorders. Overall, this protein is essential for proper erythrocyte function and survival.
Source	Rabbit
Specificity	The detection of endogenous levels of total MPP1 can be achieved using the MPP1 Antibody. This antibody specifically targets and measures the expression of MPP1 protein in a sample. By utilizing this antibody, researchers can accurately assess the quantity of MPP1 protein present in biological samples.
Species Reactivity	Human
Predictive reaction species	Xenopus;Zebrafish;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	MPP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MPP1.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly specific and targeted process, this method effectively separates the desired proteins from various other components present.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage at -20 °C is recommended. It is important to avoid repeating the freeze/thaw cycle to ensure the integrity of the sample. Keep this in mind when handling and storing the sample to achieve optimal results.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Tissue specificity	Ubiquitous.
Posttranslational modification	Extensively palmitoylated by ZDHHC17, palmitoylation is essential for membrane organization and is crucial for proper erythrocytes morphology.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q00013