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Rabbit Anti-CACNA1G Polyclonal Antibody#abs139534

Please note that the price provided is for your reference only. For detailed pricing, kindly reach out to our seller Vecent. Western blot analysis CACNA1G using 293 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs139534-100ug	1-2 Weeks	301.0
abs139534-50ug	1-2 Weeks	201.0

Please note that the price provided is for your reference only. For detailed pricing, kindly reach out to our seller Vecent.

Overview
catalog	abs139534
Other names	The Low voltage activated calcium channel alpha1 3.2 subunit, also known as Cav3.1c, is an important component of voltage dependent T type calcium channels. Other subunits include NBR13, Voltage dependent T type calcium channel subunit alpha 1G, and Voltage dependent T type calcium channel subunit alpha 1H. Together, these subunits form the Voltage gated calcium channel subunit alpha Cav3.1 and Voltage gated calcium channel subunit alpha Cav3.2. These channels are responsible for regulating calcium influx in cells, which plays a critical role in numerous physiological processes including muscle contraction, neurotransmitter release, and neuronal excitability. As such, mutations or dysregulation of these channels have been implicated in a variety of diseases including epilepsy, autism, and hypertension. Understanding the function and regulation of these channels may provide insight into the development of novel therapeutic strategies for these disorders.
Source	Rabbit
Specificity	The endogenous levels of total CACNA1G can be detected using the CACNA1G Antibody. It is designed to specifically recognize and bind to the CACNA1G protein present in the sample. This antibody allows for the identification and quantification of CACNA1G in various biological samples. By detecting the total CACNA1G levels, researchers can gain insights into its expression patterns and better understand its role in physiological and pathological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	CACNA1G
Application	The recommended dilutions for WB are between 1:1000 and 1:3000, for IHC it is 1:200, and for ELISA (peptide) it ranges between 1:20000 to 1:40000. This information can be helpful in conducting experiments involving these techniques.
Immunogen	A synthesized peptide derived from human CACNA1G.
MW	262 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at a temperature of -20 °C for a period of one year. It is important to avoid any instances of freezing and thawing the product repeatedly. Follow these guidelines to ensure the product remains safe for use.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline (PBS) with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and has a shelf life of 12 months from the date of receipt.
Target
Background	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Tissue specificity	Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.
Posttranslational modification	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
Celluar localization	Plasma Membrane;
UniPort	O43497