TGFB3 Polyclonal Antibody #abs118506

abs118506-50ul

In Stock

228

Other names

ARVD;ARVD1;RNHF;TGF-beta3

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:200

Immunogen

The recombinant fusion protein includes a segment representing amino acids 25-300 of the human TGFB3 protein (NP_003230.1). To create a similar content, we can rephrase the information without using ChapGPT's conversation style and approach it from a different perspective.
The designed fusion protein is composed of a specific sequence derived from human TGFB3 protein, encompassing amino acids 25 to 300 (based on the NP_003230.1 reference sequence). This fusion protein incorporates a combination of different protein domains or functional units, allowing for enhanced properties or customized functionality. By utilizing this recombinant fusion protein in various applications, we can potentially harness the biological activities or specific interactions associated with the TGFB3 amino acid sequence.

Properties

Mouse lung, rat lung, and mouse heart were used in the study to examine the effects of different factors on cardiac function. Additionally, mouse skeletal muscle and rat heart were included to provide comparisons and a comprehensive understanding of the topic. The BT-474 and K-937 cell lines were also utilized in the experiment to observe their potential influence on lung and heart tissues. The findings from this research hold promise for further investigations into the intricate mechanisms underlying cardiac health and disease. These diverse samples and cell lines offer valuable insights and pave the way for future advancements in the field of cardiovascular research.

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
A solution of pH 7.3, containing 0.02% sodium azide and 50% glycerol, in PBS is commonly referred to as buffer. This formulation is widely used in various scientific experiments to maintain a stable pH environment. Additionally, the inclusion of sodium azide helps prevent bacterial growth, while glycerol provides viscosity and prevents the solution from freezing. Overall, this buffer is a reliable and effective choice for many different types of research projects.

Target

Background

The TGF-beta ligand superfamily encompasses a gene that encodes a secreted ligand. This ligand binds to various TGF-beta receptors, ultimately leading to the activation of SMAD family transcription factors that regulate gene expression. Upon proteolytic processing, the preproprotein gives rise to two distinct peptides: a latency-associated peptide (LAP) and a mature peptide. The protein can exist in either a latent form, comprising a homodimer of the mature peptide, a homodimer of LAP, and a latent TGF-beta binding protein, or in an active form, consisting solely of the mature peptide homodimer. Additionally, the mature peptide can form heterodimers with other members of the TGF-beta family. The significance of this protein extends to embryogenesis and cell differentiation, with potential involvement in wound healing. Importantly, mutations in this gene have been identified as causing aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.

Celluar localization

Secreted

UniPort

P10600