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Rabbit Anti-Synuclein Beta Polyclonal Antibody#abs131421

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Description

Catalog-specification	Delivery time	USD price
abs131421-100ug	1-2 Weeks	301.0
abs131421-50ug	1-2 Weeks	201.0

Overview
catalog	abs131421
Description	The non-amyloid component discovered in senile plaques associated with Alzheimer's disease has been found to potentially regulate the aggregation process of SNCA. Additionally, it has shown to possess the ability to safeguard neurons from caspase activation induced by staurosporine and 6-hydroxy dopamine (6OHDA). Remarkably, this protective effect operates in a p53/TP53-dependent manner, underscoring its significance in neuronal preservation.
Other names	One potential way to generate highly similar content from the above text is: The 14 kDa brain-specific protein, also known as beta-synuclein or phosphoneuroprotein 14 (PNP14), is a molecule of interest in the field of neuroscience. Its primary function is not completely understood; however, it is believed to be involved in regulating neuronal activity. The SYUB_HUMAN gene encodes for this protein, which is also commonly referred to as synuclein beta. Its discovery and continued study offer promising opportunities for unraveling the mysteries of the brain and treating neurological disorders.
Source	Rabbit
Specificity	The detection of endogenous levels of total Synuclein β can be achieved using the Synuclein β Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	Synuclein β
Application	The recommended dilution range for using the primary antibody WB is between 1:500-1:2000, for IHC it is between 1:50-1:200, for IF it is between 1:100-1:500, and for ELISA(peptide) the range is between 1:20000-1:40000. It is important to note that adjusting the dilution may be necessary for optimal results based on the specific experiment and sample being used. It is always recommended to perform a titration experiment to determine the ideal dilution for your particular application.
Immunogen	Synuclein β, a peptide synthesized from the human body, serves as the foundation for deriving a highly similar content. By rearranging the provided information, we can present an alternative discourse that stays true to the original text.
MW	14 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was utilized to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at a temperature of -20 °C for a duration of one year to maintain its quality. It is advisable to avoid subjecting it to repeated cycles of freezing and thawing as this may affect its performance.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Tissue specificity	Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Posttranslational modification	Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
Celluar localization	Cytosol;Mitochondrion;
UniPort	Q16143