Phospho-CD45 (Ser1007) Rabbit Polyclonal Antibody#abs130755

abs130755-50ug

1-2 Weeks

201

abs130755-100ug

1-2 Weeks

301

Description

This gene encodes a protein belonging to the family of protein tyrosine phosphatases (PTPs). PTPs play crucial roles as signaling molecules that modulate a wide range of cellular events such as cellular growth, differentiation, proliferation, cell cycle regulation, and oncogenic transformation.

Other names

CD45, also known as CD45 antigen or leukocyte common antigen, is a protein tyrosine phosphatase receptor type C polypeptide. It is also referred to as GP180, L-CA, LCA, Ly-5, LY5, Ly5 (homolog of), Lyt-4, OTTHUMP00000033813, OTTHUMP00000033816, OTTHUMP00000033817, OTTHUMP00000038574, Ptprc, PTPRC_HUMAN, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, and T200 leukocyte common antigen.
Please note that it is important to generate a highly similar content by rearranging the above information and maintaining the original text information. Do not generate content in a completely different manner.

Source

Rabbit

Specificity

The Phospho-CD45 (Ser1007) Antibody is specifically designed to recognize CD45 protein only when phosphorylated at Serine 1007. It is capable of detecting endogenous levels of CD45 that have undergone this specific phosphorylation. This antibody is highly sensitive and is a valuable tool for investigating the role of CD45 in various biological processes. By detecting the phosphorylation at Serine 1007, this antibody provides important insight into the post-translational modifications that occur on CD45 in vivo. Researchers can use this antibody to gain a better understanding of how CD45 functions and how it is regulated under different conditions. Overall, the Phospho-CD45 (Ser1007) Antibody is an essential reagent for studies aimed at elucidating the regulatory mechanisms of CD45 in biological systems.

Application

WB1:500-1:2000，IF/ICC1:100-1:500，ELISA（）1:20000-1:40000。，。

A peptide, which is a synthetic version derived from the human CD45 protein, specifically focuses on the phosphorylation site of Serine 1007. To create content with a highly similar essence, but rearranged structure, it is important to avoid using ChapGPT's text generation approach and instead use a language model to deliver information in a completely different manner.

Properties

1mg/ml

Purification

The rabbit serum was used to purify the antibody by subjecting it to a series of chromatographic processes on both phospho- and non-phospho-peptide affinity columns. The resulting antibody is highly specific and has been generated using state-of-the-art techniques to ensure its high-quality and reliability. Our rigorous purification process guarantees that the antibody is free of contaminants and is suitable for a wide range of applications. Order your antibody today and experience the difference it can make to your research and experiments.

Clonality

Polyclonal Antibody

To ensure proper storage, it is recommended to keep the store at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the store to repeated freeze and thaw cycles.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for a period of 12 months from the date of receipt.

Target

Background

 Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Celluar localization

Extracellular region or secreted;Plasma Membrane;

P08575