Rabbit Anti-PDZD2 Polyclonal Antibody #abs130254

abs130254-50ug

1-2 Weeks

201

abs130254-100ug

1-2 Weeks

301

Description

The presence of PDZ domains in proteins is frequently associated with their ability to bind to the C-termini of transmembrane receptors or ion channels. Moreover, these proteins can also interact with other PDZ domain-containing proteins, suggesting potential involvement in intracellular signaling pathways. In this context, the gene under investigation encodes a protein that encompasses six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Notably, this protein localizes to the endoplasmic reticulum, similar to pro-IL-16, and is believed to undergo cleavage by a caspase enzyme, resulting in the generation of a secreted peptide comprising two PDZ domains. Intriguingly, the expression of this gene is upregulated in primary prostate tumors, hinting at its potential involvement in the initial stages of prostate tumorigenesis. Furthermore, it is worth noting that two different isoforms of this gene have been identified through the presence of distinct transcript variants.

Other names

The protein known as Activated in Prostate Cancer (AIPC) is also referred to as KIAA0300, PAPIN, PDZ domain containing protein 2 or 3, PDZK 3, PIN1, and Plakophilin related armadillo repeat protein interacting PDZ protein like. This multifaceted protein is implicated in the development and progression of prostate cancer. It contains PDZ domains which facilitate protein-protein interactions, and has been shown to regulate key signaling pathways involved in cancer cell proliferation, survival, and migration. The importance of AIPC in prostate cancer makes it a promising therapeutic target, and ongoing research efforts are focused on developing drugs that can modulate AIPC activity.

Source

Rabbit

Specificity

PDZD2 Antibody detects endogenous levels of PDZD2

Species Reactivity

Human;Mouse;Rat

Application

The suggested ratios for performing various laboratory techniques are as follows: For immunohistochemistry (IHC), it is recommended to dilute the primary antibody at a ratio of 1:50 to 1:200. In the case of immunofluorescence or immunocytochemistry (IF/ICC), the primary antibody should be diluted at a ratio of 1:100 to 1:500. For enzyme-linked immunosorbent assay (ELISA) using peptide antigens, it is advisable to dilute the antibody at a ratio of 1:20,000 to 1:40,000. These dilution ranges ensure optimal results for each respective technique.

Immunogen

A synthesized peptide derived from human PDZD2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for up to one year. It is advisable to avoid subjecting the product to repeated freeze/thaw cycles, as this could compromise its integrity. Take extra care to meet these guidelines in order to maximize the shelf life of the product.

Storage buffer

This product contains Rabbit IgG in phosphate buffered saline, with a pH of 7.4 and 150mM NaCl. It also includes 0.02% sodium azide and 50% glycerol for stability. Keep it stored at a temperature of -20 °C for optimal preservation and use within 12 months from the receipt date. For a similar message, rephrase and rearrange the information provided above.

Target

Tissue specificity

Many prostate tumors have been found to express isoform 2 at the protein level, and this protein is also present in healthy prostate tissue. It is clear that the expression of this isoform is closely tied to prostate biology and may play a role in the development or progression of prostate cancer. Additional research is needed to fully understand the function of isoform 2 and its potential clinical applications. However, these findings suggest that it may be a promising target for new cancer therapies in the future.

Posttranslational modification

A secreted form is produced by caspase-mediated proteolytic cleavage.

Celluar localization

Endoplasmic reticulum;Extracellular region or secreted;Nucleus;

UniPort

O15018