TGFBR1 Polyclonal Antibody #abs115165

abs115165-50ul

In Stock

228

Other names

AAT5;ACVRLK4;ALK-5;ALK5;ESS1;LDS1;LDS1A;LDS2A;MSSE;SKR4;tbetaR-I;TGFR-1

Source

Rabbit

Species Reactivity

Human,Mouse,Rat

Application

WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100

Immunogen

A fusion protein composed of a sequence identical to amino acids 34-124 found in the human TGFBR1 (NP_001124388.1) has been developed through recombinant technology.

Properties

U-251MG,22Rv1,SW480,HL-60,HeLa

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
The composition of the buffer is pH7.3 with 0.02% sodium azide and 50% glycerol. It is important to note that the buffer also contains PBS and is preserved with sodium azide. Additionally, the pH of the buffer is adjusted to 7.3 for optimal performance. Moreover, the buffer solution is formulated with 50% glycerol to enhance its stability and viscosity.

Target

Background

Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). The protein encoded by this gene functions as a serine/threonine protein kinase and forms a heteromeric complex with type II TGF-beta receptors. When bound to TGF-beta, this complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Different isoforms of the encoded protein have been identified through multiple transcript variants.

Celluar localization

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UniPort

P36897