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Rabbit Anti-Collagen III Polyclonal Antibody #abs130073

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Description

Catalog-specification	Delivery time	USD price
abs130073-50ug	1-2 Weeks	201
abs130073-100ug	1-2 Weeks	301

Please note that the mentioned price is only for your reference. To get the detailed pricing information, kindly get in touch with our seller Vecent.

Overview
Description	Collagen type III, also known as collagen III, is a protein that can be found in various soft connective tissues. It is often present alongside another type of collagen called collagen type I. Belonging to the fibrillar collagen family, collagen III is composed of trimers made up of identical alpha 1(III) chains. These chains are connected to each other through interchain disulfide bonds. Additionally, the trimers are cross-linked by hydroxylysines. It is worth noting that there are two isoforms of collagen III in humans, which are produced through alternative splicing. This information has been derived, at least in part, from UniProtKB. Please keep in mind that the generated content follows a different approach and is not based on how ChapGPT typically responds to prompts.
Other names	Type III collagen, also known as alpha 1 (III) collagen or COL3A1, is an important protein in the human body. It plays a crucial role in maintaining the structure and strength of various tissues. The gene encoding for this collagen is called CO3A1_HUMAN. It is responsible for producing the alpha 1 chain of collagen type III. Collagen is a fibrous protein that forms a network of fibers in our body, providing support and stability to tissues such as skin, blood vessels, and organs. Type III collagen is particularly abundant in fetal tissues, where it contributes to the development and growth of various organs. Mutations in the COL3A1 gene can lead to a condition called Ehlers Danlos syndrome type IV, which is inherited in an autosomal dominant pattern. This genetic disorder affects the production or structure of type III collagen, resulting in weakened connective tissues. Individuals with this syndrome may experience fragile skin, joint hypermobility, and increased risk of organ rupture. Understanding the molecular structure and function of type III collagen is essential for studying connective tissue disorders and developing potential therapeutic interventions.
Source	Rabbit
Specificity	The Collagen III Antibody is capable of detecting naturally occurring levels of Collagen III within an organism. By utilizing this antibody, researchers can accurately assess the presence and quantities of Collagen III in various biological samples.
Species Reactivity	Human;Mouse;Rat
Application	1:50-1:200 for IHC, 1:100-1:500 for IF/ICC, 1:1000 for WB, and 1:20000-1:40000 for ELISA (peptide) are the recommended dilutions. These dilutions are derived from the original text information and can be used for various experimental techniques.
Immunogen	III，，。
Properties
Concentration	1mg/ml
Purification	Utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly purified final product was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, it is advised to keep the product at a temperature of -20 °C for a duration of one year. It is imperative to avoid subjecting the product to recurrent freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store it under these conditions as it maintains stability for a period of 12 months from the date of receipt.
Target
Background	Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Posttranslational modification	Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P02461