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Rabbit Anti-Claudin4 Polyclonal Antibody#abs131449

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs131449-100ug	1-2 Weeks	301.0
abs131449-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs131449
Description	CLDN4, which is located in the critical region of Williams-Beuren syndrome (WBS), is affected by a hemizygous deletion of multiple genes on chromosome 7q11.23. This deletion is believed to occur due to unequal crossing over between closely related low-copy repeat sequences that surround the deleted region.
Other names	Claudin-4, also known as CLDN4_HUMAN or simply CLDN4, is a protein that acts as a receptor for Clostridium perfringens enterotoxin. It is also referred to as CPE R, CPE receptor, CPE-R, CPE-receptor, CPER, CPETR 1, or CPETR. This protein is encoded by the gene WBSCR8, which is also known as Williams Beuren syndrome chromosome region 8 protein or Williams-Beuren syndrome chromosomal region 8 protein. The primary function of Claudin-4 is to regulate the permeability of tight junctions between cells, which is essential for the proper functioning of epithelial barriers. Understanding the role of Claudin-4 in the human body is an important area of research, as abnormalities in its expression have been implicated in several diseases, including cancer, inflammatory bowel disease, and other gastrointestinal disorders.
Source	Rabbit
Specificity	The endogenous levels of total Claudin 4 can be detected by the Claudin 4 Antibody. This antibody is designed to specifically recognize and bind to Claudin 4 protein, allowing researchers to study its expression and localization within cells and tissues. By using this antibody, scientists can gain insights into the role and function of Claudin 4 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Dog
Antigen	Claudin4
Application	For Western Blotting (WB), the recommended dilution ranges from 1:500 to 1:2000. When it comes to Immunohistochemistry (IHC), the appropriate dilution ranges from 1:50 to 1:200. As for ELISA assays using peptides, the suggested dilution is between 1:20000 and 1:40000. Please note that this generated content is based on the original text information provided.
Immunogen	A man-made peptide composed of human Claudin 4 has been successfully developed. The peptide is structurally similar to the original protein, ensuring its effectiveness in various biological processes. The creation of this synthetic peptide opens up new opportunities for biomedical research and drug discovery, potentially leading to the development of novel therapeutics for a range of diseases and conditions.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed to purify the antiserum via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a major role in tight junction-specific obliteration of the intercellular space.
Posttranslational modification	Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Celluar localization	Plasma Membrane;
UniPort	O14493