Rabbit Anti-CIB2 Polyclonal Antibody #abs130284

abs130284-50ug

1-2 Weeks

201

abs130284-100ug

1-2 Weeks

301

Description

The protein CIB is classified as a calcium-binding protein, showcasing its crucial molecular function of binding to calcium ions.

Other names

Calcium and integrin binding protein 2, also known as Cib2 or DNA dependent protein kinase interacting protein 2, is a member of the calcium and integrin-binding family. This protein plays a crucial role in cellular processes by interacting with kinases. In particular, it serves as a kinase-interacting protein 2, or KIP 2. Cib2 functions by binding calcium and integrins, facilitating their interaction with other cellular components. Its presence is essential for maintaining proper cell signaling and ensuring normal cell function.

Source

Rabbit

Specificity

CIB2 Antibody detects endogenous levels of CIB2

Species Reactivity

Human;Mouse;Rat

Application

The recommended dilutions for the IHC assay are 1:50 to 1:200, while for Western blotting it is 1:1000. For the ELISA using peptide, the suggested dilutions range from 1:20000 to 1:40000. It is important to note that these dilutions have been determined based on the original text information.

Immunogen

A synthesized peptide derived from human CIB2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To ensure the optimal storage of the product, it is recommended to keep it at a temperature of -20 °C for a duration of one year. It is advised to abstain from subjecting the product to repeated freeze/thaw cycles, as this can cause potential damage to the product.

Storage buffer

This antibody solution contains Rabbit IgG and is formulated in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the solution at -20 °C to ensure its stability for up to 12 months from the date of receipt. To preserve its functionality, it is important to carefully follow the storage instructions.

Target

Background

This calcium-binding protein is crucial for maintaining and promoting proper function in photoreceptor cells. It also helps to maintain balance within the cell by reducing the amount of calcium that is released when ATP is present. Recent studies suggest that it may also play a role in the mechanotransduction process. Overall, this protein is vital for ensuring the healthy maintenance and optimal functioning of photoreceptor cells.

Tissue specificity

Widely expressed (PubMed:23023331).

Celluar localization

The cytoskeleton provides structural support and internal organization to the cell. It is composed of protein filaments and is located within the cell, not visible from the outside.
The extracellular region or secreted products refer to substances that are produced by the cell and released into the surrounding environment. These can include proteins, enzymes, hormones, and other molecules that play important roles in cell signaling and communication.
The plasma membrane is the outer boundary of the cell, separating the internal contents from the external environment. It is composed of a phospholipid bilayer with embedded proteins that regulate the movement of substances into and out of the cell.
In summary, the cytoskeleton is an internal structure, whereas the extracellular region refers to substances secreted by the cell, and the plasma membrane is the outer boundary of the cell.

UniPort

O75838