Rabbit Anti-TAF5L Polyclonal Antibody #abs130283

abs130283-50ug

1-2 Weeks

201

abs130283-100ug

1-2 Weeks

301

Description

TAF5L is a crucial component within the PCAF complex, which plays a significant role in acetylating histones in a nucleosomal environment. The resemblance between the PCAF complex and the yeast SAGA complex suggests that PCAF is its human counterpart. TAF5L belongs to the WD repeat TAF5 family and is part of a larger assembly of proteins known as the PCAF complex. This complex consists of various TBP-associated factors (TAFs) including TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10, and TAF12, as well as PCAF itself. Additionally, the PCAF complex recruits PCAF-associated factors (PAFs) such as TADA2L (ADA2), TADA3L (ADA3), and SPT3 to execute its functions. By rearranging the provided content, we gain insight into the critical role of TAF5L and its involvement in the PCAF complex's acetylation of histones in a nucleosomal context.

Other names

The gene 1110005N04Rik, also known as PAF65 beta or PCAF-associated factor 65 beta, is associated with TAF5 like RNA polymerase II p300/CBP-associated factor (PCAF) and plays a vital role in various cellular processes. This protein has a molecular weight of 65 kDa and is a subunit of the TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor complex. It is also known as TAF5L or Taf5l protein in scientific literature.
Research has shown that PAF65 beta is involved in the regulation of gene expression and transcription activity. It has been reported to interact with several proteins such as PCAF, GCN5, TFIID, and TBP, which are essential for the transcriptional machinery. Furthermore, PAF65 beta is implicated in cellular differentiation, cell cycle regulation, and disease pathology.
In summary, the PAF65 beta protein is a crucial factor in cellular functioning and plays a significant role in transcription regulation. Its interaction with key proteins involved in the transcriptional machinery highlights its importance in gene expression and provides further insights into cellular processes associated with this protein.

Source

Rabbit

Specificity

The TAF5L antibody is capable of identifying the complete amount of TAF5L that exists in the body naturally. To create a similar text, the information from the original content can be rephrased in a way that conveys the same message.

Species Reactivity

Human

Application

WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human TAF5L

Properties

Concentration

1mg/ml

Purification

Affinity-chromatography

Clonality

Polyclonal Antibody

Stability & Storage

To ensure optimal storage, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this may compromise its quality and effectiveness. So, be sure to follow the recommended storage guidelines to maintain the integrity of the product.

Storage buffer

The recommended storage for Rabbit IgG is at -20 °C in a solution containing phosphate buffered saline (PBS) with a pH of 7.4. The solution also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the IgG is guaranteed for a period of 12 months from the date of receipt. To maintain the integrity and functionality of the IgG, it is crucial to store it under these specified conditions.

Target

Background

The PCAF complex, similar to the yeast SAGA complex, functions as a component of histone acetylation in a nucleosomal environment. It efficiently acetylates histones within this context, making it an essential player in chromatin remodeling processes. Considered as the human equivalent of the SAGA complex, the PCAF complex plays a crucial role in regulating gene expression and maintaining the integrity of the genome. Its ability to modify histones in nucleosomes highlights its significance in modulating chromatin structure and facilitating various cellular processes.

Celluar localization

Nucleus;

UniPort

O75529