Rabbit Anti-ADA2L Polyclonal Antibody #abs130282

abs130282-50ug

1-2 Weeks

201

abs130282-100ug

1-2 Weeks

301

Description

TADA2L is an essential component of the ATAC complex, which exhibits histone acetyltransferase activity specifically on histones H3 and H4. This complex is crucial for the proper functioning of acidic activation domains, which are responsible for activating transcription from distant genetic loci. TADA2L is known to bind to double-stranded DNA and has a particular affinity for dinucleosomes, specifically at the linker region situated between adjacent nucleosomes. Additionally, TADA2L plays a significant role in the remodeling of chromatin, an important process in regulating gene expression. In terms of protein-protein interactions, TADA2L has been found to interact with GCN5 and NR3C1, further highlighting its involvement in transcriptional regulation.

Other names

The protein ADA2 is known by several names, including ADA2 like, ADA2 like protein, and Transcriptional adaptor 2 like. It is also known as ADA2, yeast, homolog of, alpha and Transcriptional adaptor 2 (ADA2 homolog, yeast) like. Another name for this protein is Transcriptional adapter 2 alpha or hADA2. It can also be referred to as KL04P or Tada2l.
Regardless of the name, ADA2 plays an important role in transcriptional regulation. It is a transcriptional adapter that helps to connect transcription factors to the transcriptional machinery. In humans, there are two ADA2 proteins: ADA2A and ADA2B.
The yeast homolog of ADA2, alpha, has been extensively studied and has been shown to play a role in histone acetylation and transcriptional activation. In humans, ADA2 is involved in a wide range of biological processes, including development, metabolism, and immunity.
Overall, ADA2 is a critical protein that is involved in many key biological processes. Understanding its function and regulation could have important implications for the treatment of a variety of diseases.

Source

Rabbit

Specificity

The total ADA2L levels in the body can be effectively determined using the ADA2L antibody. This antibody is designed to specifically detect the endogenous levels of ADA2L protein. By utilizing this antibody, researchers can gain insights into the overall amount of ADA2L present in biological samples. This detection method provides valuable information for studying the function and regulation of ADA2L in various physiological and pathological conditions.

Species Reactivity

Human;Mouse;Rat

Application

WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human ADA2L

Properties

Concentration

1mg/ml

Purification

Affinity-chromatography

Clonality

Polyclonal Antibody

Stability & Storage

To maintain optimal storage conditions, it is recommended that the product be stored at a temperature of -20 °C for a period of one year. To prevent damage to the product, avoid exposing it to repeated cycles of freezing and thawing. It is crucial to follow these guidelines to ensure the product's longevity and quality.

Storage buffer

The provided rabbit IgG is suspended in a solution containing phosphate buffered saline at a pH of 7.4 with 150mM of NaCl and 0.02% sodium azide, supplemented with 50% glycerol for preservation. It is recommended to keep the sample at a temperature of -20 °C, as it is stable for a duration of 12 months from the day of reception.

Target

Background

The ATAC complex is comprised of components that possess histone acetyltransferase activity specifically targeting histones H3 and H4. It is an essential factor for the proper functioning of acidic activation domains, which play a crucial role in activating transcription from a remote location (shown by similarity with other complexes). Moreover, it exhibits binding affinity towards double-stranded DNA. The complex's capability to bind dinucleosomes suggests its involvement in the linker region between adjacent nucleosomes. Pertinently, the ATAC complex also plays a vital role in facilitating chromatin remodeling, a process responsible for altering the structure and accessibility of DNA in chromatin.

Tissue specificity

Most prevalent in the testis, yet found in all tissues, is the expression of this gene.

Celluar localization

Nucleus;

UniPort

O75478