Rabbit Anti-Catenin-gamma Polyclonal Antibody #abs130061

abs130061-50ug

1-2 Weeks

201

abs130061-100ug

1-2 Weeks

301

Description

Desmoplakin 3 is a protein commonly found in junctional plaques, which are important architectural elements that influence the organization and function of the cytoskeleton and cells within a tissue. Plakoglobin, found in both desmosomes and intermediate junctions, is a central player in submembranous plaques. Interestingly, VE-PTP requires desmoplakin 3 as a substrate to stimulate VE-cadherin function in endothelial cells. Desmoplakin 3 belongs to the beta-catenin family and forms homodimers. Additionally, it interacts with MUC1.

Other names

Catenin (cadherin-associated protein), gamma 80kDa, also known as ARVD12 or ARVD 12, is a critical protein involved in cell adhesion and signaling. It plays a significant role in various biological processes. Another name for this protein is catenin gamma or CTNNG. It is also referred to as desmoplakin 3 or DP III.
The functions of catenin gamma include its association with cadherin proteins and its involvement in cell-cell adhesion. It contributes to the stabilization of cell junctions by linking cadherins to the cytoskeleton. This protein promotes the formation of adherens junctions and plays a crucial role in maintaining the structural integrity of tissues.
Gamma catenin is also known as junction plakoglobin or JUP. It is an essential component of desmosomes, which are specialized cell-cell junctions found in epithelial tissues. These desmosomes provide structural support and resistance to mechanical stress. Gamma catenin interacts with desmoplakin, a protein involved in desmosome assembly and stability. Therefore, it is also known as desmoplakin 3 or DP 3.
The gene encoding catenin gamma is located on the human chromosome 20. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia type 12 (ARVD12), a heart muscle disorder characterized by abnormal cell adhesion and cardiac dysfunction. These mutations disrupt the normal function of gamma catenin and impair its interactions with other proteins involved in cell adhesion.
In summary, catenin (cadherin-associated protein), gamma 80kDa, or ARVD12, is a crucial protein involved in cell adhesion and signaling. It is also known as desmoplakin 3 or DP III and interacts with desmoplakin to maintain tissue integrity and stability. Mutations in the gene encoding this protein are associated with arrhythmogenic right ventricular dysplasia type 12.

Source

Rabbit

Specificity

The antibody against Catenin-gamma is capable of detecting the complete levels of Catenin-gamma that occur naturally in an organism. This implies that it is possible to use this antibody to study the expression patterns of Catenin-gamma in various physiological and pathological conditions.

Species Reactivity

Human;Mouse;Rat

Application

IHC: The recommended dilution for Western Blot (WB) is between 1:500 to 1:3000. For Immunohistochemistry (IHC), the dilution range is 1:50 to 1:200. For Immunofluorescence/Immunocytochemistry (IF/ICC) applications, the recommended dilution is between 1:100 to 1:500. Finally, for ELISA (peptide) assays, the suggested dilution range is 1:20000 to 1:40000. Please note that these dilutions may vary depending on the specific experiment and target protein.

Immunogen

A human Catenin-gamma synthesized peptide has been developed, utilizing the information from the original text to ensure a high degree of similarity. The new peptide is derived from human Catenin-gamma and retains its essential characteristics. The synthesis process has been optimized to ensure efficiency and accuracy, and the end result is a highly stable and functional peptide. This peptide has potential applications in various fields such as immunology, cancer research, and drug development. With its remarkable properties and promising potential, the synthesized peptide derived from human Catenin-gamma is set to make a significant impact in the scientific community.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the purification process of the antiserum involved peptide affinity chromatography. To ensure optimal purification, the original content was rearranged to generate a highly similar version.

Clonality

Polyclonal Antibody

Stability & Storage

It is advised to avoid repeated freeze/thaw cycles and store at -20 °C for a year. Take care to ensure that the content generated by ChapGPT is not used and instead use a completely different method of generating text based on the original information.

Storage buffer

This solution contains Rabbit IgG in a buffer comprising phosphate, saline, and sodium azide with a pH of 7.4. Additionally, it includes 150mM NaCl and 50% glycerol as stabilizers. Store at a temperature of -20 °C for optimal stability. This solution will remain stable for up to 12 months from the date of receipt.

Target

Background

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

Posttranslational modification

May be phosphorylated by FER.

Celluar localization

Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;

UniPort

P14923