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Rabbit Anti-TGF Beta Receptor I Polyclonal Antibody#abs131446

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Description

Catalog-specification	Delivery time	USD price
abs131446-100ug	1-2 Weeks	301.0
abs131446-50ug	1-2 Weeks	201.0

Overview
catalog	abs131446
Description	，III/。III，，SMAD。TGF-beta。
Other names	This protein kinase is known by multiple names, including Activin A receptor type II like kinase 53kDa, Activin receptor like kinase 5 and Transforming growth factor beta receptor 1. It plays a crucial role in the cellular response to the TGF-beta superfamily of cytokines, regulating cell growth, differentiation and apoptosis. This receptor is encoded by the TGFBR1 gene and is highly conserved across species. Mutations in this gene have been linked to a number of diseases, including hereditary hemorrhagic telangiectasia and cancer. Understanding the function of this kinase may open up new avenues for the development of targeted therapies for these and other diseases.
Source	Rabbit
Specificity	The TGF β Receptor I Antibody is designed to identify total TGF β Receptor I levels in the body. This antibody can recognize endogenous levels of the protein, making it an effective tool for medical research and clinical diagnosis. By using this antibody, researchers can gain insights into the biological mechanisms underlying health and disease, ultimately leading to improved treatments and cures. Whether studying gene expression, protein signaling, or cellular pathways, this antibody is an invaluable tool for understanding the complex and dynamic world of human biology.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;
Antigen	TGF β Receptor I
Application	The recommended dilution ranges for various assays, including Western blotting, immunofluorescence, immunohistochemistry, and ELISA using peptide antigens, have been provided. For Western blotting, a dilution range of 1:500 to 1:2000 is suggested, while for immunofluorescence, the range is 1:100 to 1:500. For immunohistochemistry, a range of 1:50 to 1:200 is recommended, while for ELISA using peptide antigens, a dilution range of 1:20000 to 1:40000 is appropriate. These suggested dilution ranges can help ensure the accuracy and reproducibility of experimental results in various assays.
Immunogen	A synthesized peptide derived from human TGF β Receptor I.
MW	56 kDa.
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Tissue specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).
Posttranslational modification	Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding.N-Glycosylated.Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (PubMed:25893292).
Celluar localization	Endosome;Plasma Membrane;
UniPort	P36897

Western blot analysis of TGF β Receptor I expression in HepG2 cells

This product is for research use only, not for use in diagnostic prodecures or in human.

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