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Rabbit Anti-Integrin Beta4 Polyclonal Antibody#abs131445

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Description

Catalog-specification	Delivery time	USD price
abs131445-100ug	1-2 Weeks	301.0
abs131445-50ug	1-2 Weeks	201.0

Overview
catalog	abs131445
Description	Epithelial cells express integrin alpha-6/beta-4 predominantly. Additionally, the colon and placenta also show the expression of isoform beta-4D. In various tissues, including the epidermis, lung, duodenum, heart, spleen, and stomach, isoform beta-4E is found to be expressed. This highlights the diverse distribution of integrin alpha-6/beta-4 isoforms in different organs and indicates their functional role in various physiological processes.
Other names	The CD104 antigen, also known as CD 104 or gp150, is a cell surface molecule. It is also referred to as Integrin beta-4 subunit or Integrin beta-4 protein. In the human body, it is encoded by the ITGB4 gene. ITGB4_HUMAN is the gene symbol for Integrin beta 4 subunit. It plays a crucial role in cell adhesion and migration processes. Additionally, it is involved in the formation of hemidesmosomes, which are important for anchoring cells to the extracellular matrix. Understanding the functions of CD104 and its various names, such as ITG B4 and ITGB 4, can provide insights into its significance in biological processes.
Source	Rabbit
Specificity	The total Integrin β4 present in the body can be effectively detected using Integrin β4 Antibody. The antibody has the capability of detecting the endogenous levels of Integrin β4, which is crucial in various biological processes. By rearranging the original text, it can be said that Integrin β4 Antibody is designed to identify and measure the total amount of endogenous Integrin β4 in the body. This antibody is essential in detecting Integrin β4, which plays a significant role in several important biological activities.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Bovine;Horse
Antigen	Integrin β4
Application	We recommend dilutions for different applications as follows: for Western blotting (WB), a dilution range of 1:500-1:2000 is suggested; for immunohistochemistry (IHC), a dilution range of 1:50-1:200 is advised; for immunofluorescence/immunocytochemistry (IF/ICC), a dilution range of 1:100-1:500 is recommended; finally, for ELISA using peptides, a dilution range of 1:20000-1:40000 is recommended.
Immunogen	A peptide synthesized from Integrin β4 of human origin has been developed. The content derived from this molecule is highly similar to its parent structure and has been rearranged to ensure accuracy of information.
MW	202 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography, employing SulfoLink™ Coupling Resin, effectively purified the antiserum. Let me generate a highly similar content by rearranging the information from the original text.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the item at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze and thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Tissue specificity	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Posttranslational modification	Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	P16144