Rabbit Anti-EPHA7 Polyclonal Antibody #abs130470

abs130470-50ug

1-2 Weeks

201

abs130470-100ug

1-2 Weeks

301

Description

The ephrin receptor subfamily of the protein-tyrosine kinase family includes this gene, which plays a key role in developmental events, particularly in the nervous system. EPH and EPH-related receptors are known to mediate various developmental events. Typically, receptors in the EPH subfamily possess a single kinase domain and an extracellular region that contains a Cys-rich domain and 2 fibronectin type III repeats. These receptors are divided into 2 groups, based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors have proven to be vital for several essential physiological processes.

Other names

11 Cek; Embryonic brain kinase; EHK3; EK11; EPHA7_HUMAN; MDK 1; Tyrosine protein kinase receptor EHK 3; Developmental kinase 1; EHK-3; Epha7; Ephrin receptor Eph A7; EBK; EPH homology kinase 3; EPH-like kinase 11; Ephrin type A receptor 7; Ephrin type-A receptor 7; hEK11; Receptor protein tyrosine kinase HEK 11.

Source

Rabbit

Specificity

EPHA7 Antibody detects endogenous levels of EPHA7

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human EPHA7

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To ensure optimal storage conditions, it is advised to keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.

Storage buffer

This product contains rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and is stable for a period of 12 months from the date of receipt. To ensure the best results, please handle the product with care and follow the instructions provided. Whether you are a researcher or a scientist, this product can help you advance your research and make important discoveries in your field.

Target

Background

Ephrin-A ligands, which are GPI-anchored, bind to receptor tyrosine kinases in adjacent cells and initiate bidirectional signaling. This contact-dependent signaling is known as forward signaling when initiated by the receptor and reverse signaling when initiated by the ephrin ligand. The interaction between the cognate ligand EFNA5 and its receptor EPHA7 plays a crucial role in brain development by regulating cell-cell adhesion and repulsion. It acts as a repellent for axons and guides the corticothalamic and retinal axons to their proper destinations. Additionally, it can influence brain development through a proapoptotic activity that depends on caspase (CASP3). Activation of EPHA7 can lead to phosphorylation of key components of the ERK signaling pathway, including MAP2K1, MAP2K2, MAPK1, and MAPK3.

Tissue specificity

Widely expressed.

Posttranslational modification

Phosphorylated.

Celluar localization

Plasma Membrane;

UniPort

Q15375