Rabbit Anti-ABCG5 Polyclonal Antibody #abs125434

abs125434-100ul

In Stock

301

Other names

ATP binding cassette sub family G member 5 (sterolin 1), also known as ABCG5 or STSL, is a protein involved in the transportation of sterols. It belongs to the ATP-binding cassette sub-family G and plays a crucial role in regulating cholesterol metabolism. ABCG5_HUMAN, commonly referred to as Sterolin-1, is responsible for maintaining the balance of cholesterol in the body. By rearranging the given content, we can obtain a concise description of this protein and its functions.

Source

Rabbit

Specificity

ABCG5

Species Reactivity

Human;Mouse;Rat;Dog;Pig;Cow;Horse;Rabbit;

Application

ELISA，1:500-1000。（IHC-P），1:400-800。（IHC-F）（IF），1:400-800。（IF），，。，。

Immunogen

A synthetic peptide derived from human ABCG5:251-350/651 has been conjugated with KLH. To ensure the content is highly similar to the original text, the expressed information will be rearranged in a new way. The synthetic peptide is designed to mimic a specific region of the human ABCG5 protein, which is involved in cholesterol metabolism. The KLH conjugation allows for the peptide to be presented to the immune system in a way that can generate an immune response. This synthetic peptide can be used in research to study the function of ABCG5 in cholesterol transport and homeostasis, as well as to investigate potential treatments for disorders related to cholesterol metabolism.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing.

Storage buffer

A solution consisting of 0.01M TBS at a pH level of 7.4 is prepared by adding 1% BSA, 0.03% Proclin300, and 50% Glycerol. The resulting mixture is highly stable and can be used in various applications such as protein assays, western blots, and ELISAs. The addition of BSA and Proclin300 serves to reduce non-specific binding and protein aggregation while the glycerol aids in preventing sample evaporation. This solution is an excellent choice for researchers who require a reliable and effective reagent for their experiments.

Research area

Immunology is a field of study that focuses on the body's immune system and how it defends against diseases, including tumor cells. In tumor cell biology, researchers examine the characteristics and behavior of these abnormal cells to better understand their development and progression. One important aspect of tumor cell biology is the role of transcription regulators, which are proteins that control gene expression and can influence the behavior of tumor cells. Additionally, transporters play a crucial role in moving substances across cell membranes, including nutrients and waste products. Binding proteins are another key component, as they can bind to specific molecules and regulate their activity. By delving into these different areas of research, scientists strive to gain insight into the mechanisms underlying tumor growth and devise effective strategies for diagnosis and treatment.

Target

Background

This particular gene encodes for a protein that forms part of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins play a crucial role in transporting various molecules across intra- and extracellular membranes. There are seven subfamilies of ABC genes, including ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. The protein that this gene encodes belongs to the White subfamily and functions as a half-transporter. Its role is to limit the absorption of sterols in the intestine and promote their excretion in bile. The gene is expressed in a tissue-specific manner in the liver, colon, and intestine. It is located on chromosome 2 and is arranged in a head-to-head orientation with the ABCG8 gene. Mutations in this gene have been linked to the accumulation of sterols and the development of atherosclerosis, and have been identified in individuals suffering from sitosterolemia. This information was provided by RefSeq in July of 2008.

Celluar localization

Cell membrane

UniPort

Q9H222