Rabbit Anti-TRAF6 Polyclonal Antibody #abs121457

abs121457-50ul

In Stock

201

abs121457-100ul

In Stock

301

Other names

Here are a few variations on the original text:
- TRAF6, also known as TNF receptor-associated factor 6, is a key player in the signaling pathways of interleukin 1. This protein is also referred to as RING finger protein 85 or RNF85. TRAF6 is involved in various biological processes such as immunity, inflammation, and bone metabolism. Its dysregulation has been linked to several diseases, including autoimmune disorders, osteoporosis, and cancer.
- MGC3310 is a gene that encodes for a protein called TRAF6_HUMAN, which is also known as TNF receptor-associated factor 6. This protein acts as a signal transducer for interleukin 1 and other cytokines. RNF85 is another name for TRAF6, which refers to its structural motif known as the RING finger domain. TRAF6 is a multifaceted protein that interacts with other molecules to regulate a variety of cellular activities, such as the innate immune response, bone remodeling, and cell differentiation.
- Interleukin 1 is a cytokine that engages with its receptor on the surface of target cells and triggers a cascade of intracellular events. TNF receptor-associated factor 6, or TRAF6, is a critical adapter protein that mediates IL-1 signaling and amplifies its effects. TRAF6_HUMAN is the human homolog of TRAF6, which contains a RING finger motif that confers ubiquitin ligase activity. MGC3310 is the Human Genome Organization (HUGO) symbol for the TRAF6 gene. RNF85 is another alias for TRAF6, referring to its location on chromosome 11 and its molecular weight of 85 kDa.

Source

Rabbit

Specificity

TRAF6

Species Reactivity

Human;Mouse;Rat;

Application

ELISA-1:500-1000;
IHC-P-1:400-800;
IHC-F-1:400-800;
IF-1:100-500 (requires antigen retrieval for paraffin section).

Immunogen

:
TRAF6:441-530/530KLH。。

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Please make sure to avoid repeated freeze/thaw cycles and store the product at -20°C for one year. It is important to maintain this temperature to preserve the quality of the item.

Storage buffer

TBS (pH 7.4) with 1% BSA, 0.03% Proclin300, and 50% Glycerol is a solution with the following components. The TBS buffer, at a pH of 7.4, serves as the base for this solution. It is supplemented with 1% BSA (bovine serum albumin), which acts as a protein stabilizer. Additionally, 0.03% Proclin300 is included for preservation purposes, preventing microbial growth. Lastly, the solution contains 50% glycerol, which serves as a cryoprotectant and helps maintain the stability of biologically active molecules.

Research area

Cell membrane receptors play a crucial role in tumor signal transduction, leading to apoptosis.

Target

Background

This gene encodes a protein that belongs to the TRAF protein family, which is involved in mediating signal transduction from TNF and Toll/IL-1 receptors. It plays a crucial role in transmitting signals not only from TNF receptors but also from members of the Toll/IL-1 family. Specifically, it has been shown to mediate signaling from CD40, TNFSF11/RANCE, and IL-1 receptors. This protein interacts with several protein kinases, including IRAK1/IRAK, SRC, and PKCzeta, thereby establishing connections between different signaling pathways. It acts as a signal transducer in the NF-kappaB pathway, activating IKK in response to proinflammatory cytokines. Importantly, its interaction with UBE2N/UBC13 and UBE2V1/UEV1A, which are enzymes involved in forming polyubiquitin chains, is necessary for IKK activation. There are two alternative forms of the transcript for this gene, both encoding the same protein. (RefSeq)

UniPort

P70196