TRIM21 Polyclonal Antibody #abs115870

abs115870-50ul

In Stock

228

Other names

RNF81;Ro/SSA;RO52;SSA;SSA1

Source

Rabbit

Species Reactivity

Human

Application

WB1:500-1:2000
IF1:10-1:100
IP1:10-1:100

Immunogen

A fusion protein has been produced through genetic manipulation, consisting of a particular sequence from human TRIM21. This sequence is composed of amino acids numbered 80 to 330, as described in the accession code NP_003132.2. The resulting fusion protein should be similar to the original TRIM21 protein in terms of its structure and function.

Properties

A-549,U-937,SW620,HT-29,U-251MG

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
A solution of pH 7.3 containing 0.02% sodium azide and 50% glycerol is commonly used as PBS buffer. Sodium azide works as a preservative in the solution, while glycerol acts as a stabilizer. The solution is an effective tool for various research applications where the maintenance of physiological pH is crucial.

Target

Background

This particular gene belongs to the tripartite motif (TRIM) family, which contains three zinc-binding domains: a RING, a B-box type 1 and a B-box type 2, as well as a coiled-coil region. The RoSSA ribonucleoprotein complex consists of a single polypeptide and four small RNA molecules and can be found in both the cytoplasm and the nucleus. RoSSA has been shown to interact with autoantigens in individuals with Sjogren syndrome and systemic lupus erythematosus. Although multiple variants of this gene have been identified, only one has been fully characterized.

Celluar localization

The cell contains various components such as cytoplasm, the nucleus, cytoplasmic vesicles, p-bodies, and autophagosomes. These elements play critical roles in maintaining the integrity of the cell. The cytoplasm is where most cellular processes take place, and it contains a variety of organelles, including cytoplasmic vesicles, which can store and transport substances within the cell. The nucleus is the control center of the cell and contains the genetic material. P-bodies are structures that regulate gene expression and RNA degradation, while autophagosomes break down and recycle cellular components. Together, these components work to ensure the proper functioning of the cell and maintain its homeostasis.

UniPort

P19474