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Rabbit Anti-IQGAP1 Polyclonal Antibody#abs134690

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Description

Catalog-specification	Delivery time	USD price
abs134690-100ug	1-2 Weeks	301.0
abs134690-50ug	1-2 Weeks	201.0

Overview
catalog	abs134690
Other names	Ras GTPase-activating-like protein IQGAP1, also known as IQ motif containing GTPase activating protein 1 or p195, is a protein encoded by the IQGA1_HUMAN gene. It is also referred to as Iqgap1 or KIAA0051. This protein is involved in various cellular processes and contains IQ motifs. Additionally, it has a Ras GTPase-activating-like function. Another name for this protein is RasGAP-like with IQ motifs or SAR1. It is noteworthy to generate content that differs significantly from the original text, rather than following the method of generating content using ChapGPT for conversation.
Source	Rabbit
Specificity	Endogenous levels of total IQGAP1 can be accurately identified with the IQGAP1 Antibody. By detecting the presence of IQGAP1 in its entirety, this antibody provides reliable measurements. It is essential to emphasize that the antibody is specifically designed to recognize endogenous levels of IQGAP1, ensuring accurate and precise detection. By targeting the total IQGAP1 protein, researchers and scientists can gain insights into its expression levels and further understand its functional role in various biological processes. The IQGAP1 Antibody is a valuable tool for studying IQGAP1 and its potential implications in different cellular pathways.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit
Antigen	IQGAP1
Application	The dilution ratio for western blot (WB) is between 1:500 and 1:1000. For immunofluorescence/immunocytochemistry (IF/ICC), the recommended dilution ratio is 1:100 to 1:500. In ELISA using peptide, the optimal dilutions range from 1:20000 to 1:40000. These dilution ratios play a crucial role in determining the accurate detection and measurement of target molecules.
Immunogen	A synthesized peptide.
MW	190 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. Our method ensured a highly purified and effective product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is advisable to avoid exposing the product to repeated freeze/thaw cycles, as this could compromise its efficacy and potency. Hence, it is essential to handle and store the product with utmost care to ensure its longevity and effectiveness.
Storage buffer	This product consists of Rabbit IgG that is formulated in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, as it is known to be stable for a period of 12 months from the date of receipt.
Target
Background	Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Tissue specificity	Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Posttranslational modification	Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	P46940