Rabbit Anti-TGM2 Polyclonal Antibody #abs130410

abs130410-50ug

1-2 Weeks

201

abs130410-100ug

1-2 Weeks

301

Description

Transglutaminase 2 (TGM2) is an enzyme that belongs to the transglutaminase family. It plays a crucial role in catalyzing the crosslinking of proteins and the conjugation of polyamines to proteins. Although the primary structure of transglutaminases varies, they all have the same amino acid sequence at their active sites and their activity is dependent on calcium. The protein encoded by the TGM2 gene acts as a single unit, and it is stimulated by retinoic acid. It is primarily involved in processes such as apoptosis, cellular differentiation, and matrix stabilization. Furthermore, TGM2 serves as the autoantigen in coeliac disease, a condition characterized by gluten intolerance. Through its diverse functions, TGM2 contributes significantly to various biological processes and has important implications for both health and disease.

Other names

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Source

Rabbit

Specificity

TGM2 Antibody detects endogenous levels of TGM2

Species Reactivity

Human;Mouse

Application

The recommended dilutions for WB are between 1:500 and 1:2000, while for IHC, they are between 1:50 and 1:200. When it comes to ELISA using peptide, the recommended dilution is between 1:20000 and 1:40000. These dilutions have been carefully selected to ensure optimal results for your experiments. It is important to adhere to these guidelines in order to achieve accurate and reliable data. Always consult the protocol provided by the manufacturer for further instructions on how to prepare and dilute the antibodies before use in your experiments.

Immunogen

A synthesized peptide derived from human TGM2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. Repeated freezing and thawing should be avoided to prevent any potential damage to the product.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the Rabbit IgG is guaranteed for a period of 12 months from the date of receipt. It is important to ensure that the content generated is highly similar to the original text information by rearranging the given information.

Target

Background

This enzyme facilitates the formation of protein cross-links and the addition of polyamines to proteins. To rephrase this, the catalyst is responsible for promoting the linkage of proteins and the attachment of polyamines to those proteins.

Tissue specificity

By retinoic acid.

Celluar localization

Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Mitochondrion;Plasma Membrane;

UniPort

P21980