Rabbit Anti-TINF2 Polyclonal Antibody #abs130325

abs130325-50ug

1-2 Weeks

201

abs130325-100ug

1-2 Weeks

301

Other names

There are several variant names for this gene, including TRF1 interacting nuclear factor 2, TERF1 interacting nuclear factor 2, and Tin 2. Another variation includes TINF 2, while some refer to it as TINF2_HUMAN. Essentially, these names all refer to the same gene, which plays an essential role in nuclear function. TERF 1 interacting nuclear factor 2 is specifically involved in the regulation of telomere maintenance and chromosomal stability. Despite the various names used to refer to this gene, its importance in maintaining the integrity of our DNA cannot be understated. Understanding its functions can provide valuable insights into the development of targeted therapies for various diseases.

Source

Rabbit

Specificity

TINF2 Antibody detects endogenous levels of TINF2.

Species Reactivity

Human

Predictive reaction species

Pig;Dog;

Application

For Western blotting, the recommended dilution range is 1:500 to 1:2000. For immunofluorescence and immunocytochemistry, the ideal dilution range is 1:100 to 1:500. When using ELISA for peptide detection, the suggested dilution range is 1:20000 to 1:40000. These dilution ranges have been carefully determined for optimal results and should be followed closely for accurate and reliable data. By using the appropriate dilution factors, researchers can achieve robust and consistent results across different experimental conditions.

Immunogen

A synthesized peptide derived from human TINF2.

Properties

Concentration

1mg/ml

Purification

To obtain a purified antiserum, SulfoLink™ Coupling Resin was utilized in the process of peptide affinity chromatography.

Clonality

Polyclonal Antibody

Stability & Storage

To ensure proper storage, it is recommended to keep the item at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting it to repeated freeze/thaw cycles.

Storage buffer

The storage conditions for Rabbit IgG are at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that this product has a shelf life of 12 months from the date of receipt.

Target

Background

The shelterin complex (telosome) is a crucial component involved in managing telomere length and protection. It works in partnership with telomerase to attach to arrays of double-stranded TTAGGG repeats and shield chromosome ends. Without this protective mechanism, telomeres become exposed to DNA damage surveillance and are vulnerable to processing by DNA repair pathways. The assembly of shelterin complex relies on the active participation of this component. In addition, isoform 1 may also function in anchoring telomeres to the nuclear matrix.

Tissue specificity

The protein has been found to be present in multiple organs, including the heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Its wide distribution across these vital organs suggests that the protein may play an essential role in regulating crucial physiological processes throughout the body. These findings highlight the need for further research and investigation into the functions and mechanisms of this protein in each of these organs. Understanding its role in different tissues and contexts could provide new insights into potential therapeutic strategies for a range of diseases and conditions.

Celluar localization

Nucleus;

UniPort

Q9BSI4