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SIGMAR1 Polyclonal Antibody #abs116683

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Description

Catalog-specification	Delivery time	USD price
abs116683-50ul	In Stock	228

Overview
Other names	ALS16;DSMA2;hSigmaR1;OPRS1;SIG-1R;sigma1R;SR-BP;SR-BP1;SRBP
Source	Rabbit
Species Reactivity	Human;Mouse;Rat
Application	WB 1:500 - 1:2000 IHC 1:100 - 1:200
Immunogen	Recombinant protein of human SIGMAR1
Properties	HL-60,293T,SKOV3,Mouse liver,Rat liver
Properties
Purification	Affinity purification
Isotype	IgG
Stability & Storage	Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. The pH of the buffer solution is 7.3 and it contains 0.02% of sodium azide along with 50% glycerol. Additionally, it has been prepared in PBS for optimum efficacy.
Target
Background	This particular gene is responsible for coding a receptor protein that interacts with various psychotomimetic drugs, such as amphetamines and cocaine. This receptor plays a crucial role in the cellular activities of multiple tissues associated with the nervous, immune, and endocrine systems. Previously named as opioid receptor sigma 1 (OPRS1), this particular gene was initially assumed to function as an opioid receptor, but it is now believed to be a non-opioid receptor. Mutations in this gene have been linked to juvenile amyotrophic lateral sclerosis 16. Several distinct isoforms are available from alternative splicing of this gene, resulting in transcript variants with unique characteristics.
Celluar localization	The cell is composed of various structures that perform specific functions. Among these structures are the cell junction, cell membrane, cell projection, endoplasmic reticulum membrane, lipid droplet, nucleus inner membrane, nucleus outer membrane, and growth cone. The cell junction is responsible for connecting adjacent cells to each other, forming a strong bond that keeps them together. The cell membrane serves as a barrier that separates the inside of the cell from its external environment. The cell projection, on the other hand, helps the cell move around and respond to its surroundings. The endoplasmic reticulum membrane is a complex system of membranes that work together to transport and synthesize proteins and lipids. The lipid droplet is a specialized organelle that stores lipids and helps regulate their release to other parts of the cell. The nucleus inner membrane surrounds the nucleus and helps regulate the transport of molecules in and out of the nucleus. The nucleus outer membrane, on the other hand, protects the nucleus and helps maintain its shape. Lastly, the growth cone is a specialized structure that guides the growth of nerve cells and helps them establish connections with other cells. Overall, these structures work together to ensure the proper functioning of the cell and its various processes.
UniPort	Q99720