TOLLIP Polyclonal Antibody #abs116062

abs116062-50ul

In Stock

228

Other names

IL-1RAcPIP

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Immunogen

A fusion protein with a sequence that matches amino acids 1-274 of the human TOLLIP (NP_061882.2) can be created through genetic recombination. This recombinant fusion protein will possess a sequence identical to the specified range of amino acids derived from the human TOLLIP protein. The fusion protein is formed by combining the desired amino acid sequence with another protein or peptide. This fusion allows for the functional properties of the TOLLIP sequence to be preserved, while potentially incorporating additional functional elements from the fusion partner protein.

Properties

：
Mouse spleen, Mouse intestine, Mouse liver, SW480, OVCAR-3, MCF-7, 293T. These are different cell lines commonly used in scientific research. SW480 is a colorectal cancer cell line derived from a primary tumor, while OVCAR-3 is an ovarian cancer cell line. MCF-7 is a breast cancer cell line, and 293T is a human embryonic kidney cell line. As for the mouse tissues, the spleen is an important component of the immune system, the intestine plays a crucial role in digestion and absorption, and the liver is responsible for various metabolic functions in the body. All of these cell lines and tissues are extensively studied to investigate different diseases and physiological processes.

Properties

Purification

Affinity purification

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
pH7.3, 50% glycerol, PBS with 0.02% sodium azide—this formulation is commonly used.

Target

Background

There are multiple transcript variants of this gene, each encoding various isoforms. These isoforms play a crucial role in regulating inflammatory signaling and have an interaction with several components of the Toll-like receptor (TLR) signaling cascade. Additionally, they are involved in the turnover of IL1R-associated kinase and participate in the trafficking of the interleukin-1 receptor. This gene also encodes a ubiquitin-binding protein, emphasizing its ability to bind to ubiquitin molecules.

Celluar localization

Cytoplasm

UniPort

Q9H0E2