Rabbit Anti-ACV1B Polyclonal Antibody#abs131600
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Description
| Catalog-specification | Delivery time | USD price |
abs131600-50ug | 1-2 Weeks | 201.0 |
abs131600-100ug | 1-2 Weeks | 301.0 |
Please note that the price mentioned is only for your reference. For detailed pricing information, kindly reach out to our sales representative, Vecent. Instead of following the conversation style used by ChapGPT, I will address the audience in a distinct manner using a text generation approach.
| Overview | |
catalog | abs131600 |
Description | The activin type-1 receptor, a transmembrane serine/threonine kinase, forms a complex with activin receptor type-2 (ACVR2A or ACVR2B) at the cell surface. This receptor complex plays a crucial role in transmitting the activin signal from the cell surface to the cytoplasm. Consequently, it regulates various physiological and pathological processes such as neuronal differentiation and survival, hair follicle development and cycling, follicle-stimulating hormone (FSH) production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. Moreover, activin is believed to have a paracrine or autocrine function in the development of ovarian follicles. |
| Other names | The Activin A receptor type 1B, also known as ACVRLK 4 or ALK-4, is a serine/threonine protein kinase receptor that plays a crucial role in mediating various cellular processes. It is involved in the regulation of cell growth, differentiation, and apoptosis. Furthermore, Activin A receptor type II like kinase 4, Activin A type IB receptor, Activin A type IB receptor-like kinase 4, and Activin receptor-like kinase 4 are alternative names for ACVRLK 4. The protein encoded by the ACVRLK 4 gene is a transmembrane receptor that binds to the Activin A ligand and transduces its signal via the SMAD pathway. This pathway plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of ACVRLK 4 has been implicated in various diseases, including cancer, cardiovascular disease, and skeletal disorders. ACVRLK 4 is a potential therapeutic target for various diseases, and significant efforts are being made to develop specific inhibitors and agonists that can modulate its activity. These drugs may have significant implications in the treatment of various diseases, including cancer, cardiovascular disease, and bone disorders. |
| Source | Rabbit |
| Specificity | The ACV1B Antibody has the ability to detect the endogenous levels of total ACV1B protein. By using this antibody, scientists can accurately measure the amount of ACV1B present in a biological sample. This information is crucial for studying the role and function of ACV1B in various biological processes. With the ACV1B Antibody, researchers can gain insights into the physiological and pathological conditions associated with ACV1B expression. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Sheep;Bovine;Horse;Rabbit |
| Antigen | ACV1B |
| Application | Possible rearranged content: If you are planning to use Western blotting to detect a protein of interest, dilute your primary antibody at a range of 1:500 to 1:2000. For immunofluorescence experiments, the recommended dilution for the primary antibody is between 1:100 and 1:500. When performing ELISA assays with a peptide antigen, you should use your primary antibody at a dilution of 1:20000 to 1:40000. To obtain reliable and specific results, it is important to optimize the antibody dilutions for each assay type and target protein. Dilution factors that are too high can lead to weak or false-positive signals, while too low dilutions can result in high background or even no signal at all. Depending on the antibody quality, the sample type, and the experimental conditions, you may need to adjust the dilution range accordingly. It is also advisable to use appropriate positive and negative controls, secondary antibodies, blocking agents, and detection systems to maximize the accuracy and sensitivity of your immunodetection experiments. Commonly used blocking agents include BSA, milk, and non-fat dry milk, which can reduce non-specific binding of the antibody to the membrane or the sample. Secondary antibodies should be chosen based on the host species of the primary antibody and the conjugated label (e.g., HRP, FITC, Alexa Fluor). Finally, the choice of detection system (e.g., ECL, chemiluminescence, fluorescence) should depend on the level of sensitivity required and the availability of appropriate instrumentation. |
| Immunogen | A synthesized peptide derived from human ACV1B. |
| MW | 56 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. |
| Tissue specificity | Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. |
| Posttranslational modification | Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7.Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex.Ubiquitinated. |
| Celluar localization | Cytosol;Extracellular region or secreted;Plasma Membrane; |
| UniPort | P36896 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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