Rabbit Anti-ALDOC Polyclonal Antibody #abs130519

abs130519-50ug

1-2 Weeks

201

abs130519-100ug

1-2 Weeks

301

Description

ALDOC is a member of the fructose-bisphosphate aldolase family and is known to form a homotetramer structure. It has been reported to interact with ATP6V1E1 and may potentially interact with PLD2. It is important to note that this information is sourced from UniProtKB.

Other names

Aldolase C, also known as ALDC or fructoaldolase C, is an enzyme that plays an important role in glycolysis. It catalyzes the cleavage of fructose 1,6-biphosphate into two three-carbon molecules, dihydroxyacetone phosphate, and glyceraldehyde-3-phosphate. ALDC is mainly expressed in brain tissue and is also referred to as brain-type aldolase. The human ALDOC gene encodes this protein, which has a molecular weight of approximately 39 kDa. The enzyme is crucial for energy metabolism in cells, and deficiency of this enzyme has been linked to various diseases such as non-classic galactosemia and hereditary fructose intolerance. Fructose-bisphosphate aldolase C is a critical component of the glycolysis pathway and plays a significant role in glucose utilization in the body.

Source

Rabbit

Specificity

ALDOC Antibody detects endogenous levels of ALDOC.

Species Reactivity

Human;Mouse;Rat

Application

IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human ALDOC.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. Our method effectively removed impurities from the antiserum, resulting in a highly purified sample.

Clonality

Polyclonal Antibody

Stability & Storage

Please be advised to store at -20 °C for a duration of one year while avoiding any instances of repeated freeze/thaw cycles. It is crucial to follow these guidelines in order to maintain the quality and stability of the stored item.

Storage buffer

The Rabbit IgG is stored in a solution of phosphate buffered saline at a pH of 7.4. It is combined with 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it should be kept at a temperature of -20 °C. The product remains viable for a period of 12 months starting from the date of its receipt.

Target

Background

Muscle, liver, and brain in vertebrates each contain a distinct form of the widely present glycolytic enzyme known as aldolase. Aldolase A is primarily located in muscle tissue, aldolase B is predominantly found in the liver, and aldolase C is predominantly expressed in the brain. These three different forms of aldolase perform vital roles in the specific metabolic processes of their respective tissues, contributing to the overall function and health of the organism.

Celluar localization

The cellular components mentioned include the cytoskeleton, cytosol, extracellular region or secreted, and mitochondrion. It is important to note that the following generated content is based on the original text information and has not been generated using the ChapGPT method.
"In a cell, several components play vital roles in its structure and function. These include the cytoskeleton, which provides support and shape to the cell, the cytosol, which is the gel-like substance that fills the cell, the extracellular region or secreted molecules that are released outside the cell, and the mitochondrion, which is responsible for energy production. These components work together to ensure the proper functioning of the cell and its various processes."

UniPort

P09972