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Rabbit Anti-JMJD1B Polyclonal Antibody#abs132796

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Description

Catalog-specification	Delivery time	USD price
abs132796-100ug	1-2 Weeks	301.0
abs132796-50ug	1-2 Weeks	201.0

Overview
catalog	abs132796
Description	This particular histone demethylase has a crucial role in the regulation of the histone code, as it specifically targets the 'Lys-9' residue of histone H3 for demethylation. The result of this demethylation process is the generation of formaldehyde and succinate. It is believed that this enzyme may also possess tumor suppressor activity.
Other names	C5orf7; JHDM2B; JmjC domain-containing histone demethylation protein 2B; Jumonji domain-containing histone demethylation protein 2B; KDM3B; KDM3B_HUMAN; Jumonji domain-containing protein 1B; Jumonji domain-containing protein 1B; Lysine (K) specific demethylase 3B; Lysine-specific demethylase 3B; NET22; KIAA1082; Nuclear protein 5qNCA;. These are various names associated with the protein known as JmjC domain-containing histone demethylation protein 2B or KDM3B. It plays a significant role in the regulation of gene expression by removing methyl groups from histone proteins. This protein is also known as Jumonji domain-containing protein 1B and is involved in various cellular processes, including development and differentiation. It functions as a lysine-specific demethylase and is crucial for maintaining the proper epigenetic landscape within cells. The protein 5qNCA or NET22 is a nuclear protein that may have a role in transcriptional regulation. These names represent different aspects and characteristics of the same protein, highlighting its significance in cellular processes.
Source	Rabbit
Specificity	Total JMJD1B levels can be detected using the JMJD1B antibody, which specifically recognizes endogenous JMJD1B.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	JMJD1B
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	240 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum. Let me generate a completely unique content using a different approach of text generation, rather than following the dialogue generation method of ChapGPT.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Tissue specificity	Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
Celluar localization	Nucleus;
UniPort	Q7LBC6