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Rabbit Anti-POGZ Polyclonal Antibody#abs132798

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Description

Catalog-specification	Delivery time	USD price
abs132798-100ug	1-2 Weeks	301.0
abs132798-50ug	1-2 Weeks	201.0

Overview
catalog	abs132798
Description	Mitotic cell cycle progression is largely influenced by the vital role played by a protein that is involved in kinetochore assembly and mitotic sister chromatid cohesion. In all likelihood, this protein associates with CBX5 and actively participates in the segregation of mitotic chromosomes. It regulates the activation of aurora kinase B/AURKB and is instrumental in driving the dissociation of AURKB and CBX5 from chromosome arms. Its crucial contribution towards the coordination of mitotic events is undeniable.
Other names	POGZ is a notable gene encoding a putative protein known as KIAA0461 or MGC71543. This protein consists of a Pogo transposable element with a zinc finger (ZNF) domain. In humans, it is referred to as POGZ_HUMAN or by its alternative names, such as SUHW5, suppressor of hairy wing homolog 5, Zinc finger protein 280E, Zinc finger protein 635, ZNF280E, ZNF635, or ZNF635M. POGZ is believed to have a significant role in biological processes, although its exact function is yet to be fully understood.
Source	Rabbit
Specificity	The total POGZ levels in the body can be accurately detected by the POGZ antibody, which specifically targets the endogenous POGZ protein.
Species Reactivity	Human
Antigen	POGZ
Application	The recommended dilution range for Western blot is between 1:500 and 1:2000, while for immunohistochemistry it's between 1:50 and 1:200. For ELISA using peptide, the recommended dilution range is between 1:20000 and 1:40000. It's important to take note of these dilution ranges for proper detection of the target protein in your experiment.
Immunogen	A synthesized peptide.
MW	155 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography, resulting in a highly refined product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and effectiveness of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this could compromise its integrity and potency. Therefore, it is crucial to follow the storage instructions to ensure the optimal performance of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
Celluar localization	Cytosol;Nucleus;
UniPort	Q7Z3K3