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Rabbit Anti-AIF1 Polyclonal Antibody#abs135962

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Description

Catalog-specification	Delivery time	USD price
abs135962-50ug	1-2 Weeks	201.0
abs135962-100ug	1-2 Weeks	301.0

Overview
catalog	abs135962
Description	Cytokines and interferon stimulate the expression of this particular gene. The resulting protein product is believed to play a role in restricting the growth of vascular smooth muscle cells, thereby contributing to the body's anti-inflammatory response against injuries to the vessel wall. It is worth noting that three different versions of RNA transcripts, encoding distinct isoforms, have been identified for this gene. This information was sourced from RefSeq in September 2008.
Other names	The AIF-1 protein, also known as allograft inflammatory factor 1, is a highly important factor involved in various biological processes. It is also referred to as IBA1 (ionized calcium binding adapter molecule 1), IRT1 (interferon responsive transcript 1), and MRF1 (microglia response factor). AIF-1 is an interferon gamma-responsive transcript that plays a crucial role in immune response and inflammation. It is involved in the activation of macrophages and microglia, as well as in the development and migration of these cells. AIF-1 may also play a role in the pathogenesis of autoimmune diseases and chronic inflammation, as well as in the progression of cancer. The protein is encoded by the AIF1 gene, and various splice variants of the gene have been identified, including the G and Hara-1 variants. AIF-1 is also known as the BART 1 protein and is an important transcription factor that responds to balloon angioplasty. In conclusion, AIF-1 is a multifunctional protein that plays an important role in the immune response and inflammation, making it a potential target for various therapeutic interventions.
Source	Rabbit
Specificity	The AIF1 Antibody is capable of detecting total AIF1 at endogenous levels. This means that it can accurately identify the presence of this particular protein without any external interference. Reorganizing the original content allows us to convey the same message using different wording and structure, but with the same underlying meaning.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig
Antigen	AIF1
Application	The dilutions for Western blotting range from 1:500 to 1:2000, for immunohistochemistry from 1:50 to 1:200, for immunofluorescence/immunocytochemistry from 1:100 to 1:500, and for ELISA using a peptide as the antigen from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human AIF1.
MW	17kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Tissue specificity	Detected in T-lymphocytes and peripheral blood mononuclear cells.
Posttranslational modification	Phosphorylated on serine residues.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;
UniPort	P55008