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Rabbit Anti-IL-2Rbeta/CD122 Polyclonal Antibody #abs130040

Description

Catalog-specification	Delivery time	USD price
abs130040-50ug	1-2 Weeks	201
abs130040-100ug	1-2 Weeks	301

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Overview
Description	The beta subunit of the IL2RB receptor plays a crucial role in receptor-mediated endocytosis and transduces the mitogenic signals of interleukin-2. This receptor falls under the type I cytokine receptor family and belongs to the type 4 subfamily. The IL2RB receptor is composed of a non-covalent dimeric alpha and beta subunit configuration. By rearranging the information presented above, we can conclude that the beta subunit is a significant component of the IL2RB receptor, and it is responsible for important mechanisms that facilitate signal transduction. In the context of cytokine receptors, the IL2RB receptor is categorized as a type I cytokine receptor family member within the type 4 subfamily. The IL2RB receptor is composed of two subunits, an alpha and a beta subunit, which come together to form a non-covalent dimer.
Other names	The IL-2 receptor beta subunit, also known as CD122 or IL2RB, is a protein involved in the immune system. It plays a crucial role in binding to interleukin-2 (IL-2) and mediating the cellular responses to this cytokine. The CD122 antigen, or IL-2 receptor subunit beta, is characterized by its high affinity for IL-2. It forms a heterotrimeric complex with IL-2 receptor alpha (CD25) and IL-2 receptor gamma (CD132), which enables the signal transduction upon IL-2 binding. IL-2RB, also referred to as p70-75 or p75, is critical for IL-2-mediated signaling and T-cell proliferation. It is expressed on various immune cell types, including T cells, B cells, and natural killer (NK) cells. IL15RB, or IL-15 receptor subunit beta, shares structural similarities with IL-2RB and is involved in IL-15 signaling. It forms a complex with IL-15 receptor alpha (IL-15Rα) and IL-2 receptor gamma chain (IL-2Rγ) to initiate cellular responses to IL-15. Overall, the IL-2 receptor subunit beta plays a vital role in immune responses and is a target for therapeutic interventions in diseases related to the dysregulation of IL-2 signaling.
Source	Rabbit
Specificity	The antibody specifically recognizes and binds to the IL-2Rbeta/CD122 protein, allowing for detection of native levels of total IL-2Rbeta/CD122 in biological samples. The high specificity of the antibody ensures accurate measurement of IL-2Rbeta/CD122 levels in various applications. Overall, utilizing this antibody provides a reliable method for studying the expression and function of IL-2Rbeta/CD122 in both normal and disease states.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Sheep;Dog;Horse;Bovine;
Application	For Western Blot applications, the recommended dilution range is between 1:500 to 1:3000, while for Immunohistochemistry, the dilution range is between 1:50 to 1:200. If you're performing Immunofluorescence or Immunocytochemistry, it is suggested to dilute the antibody between 1:100 to 1:500. For ELISA assays using the peptide, dilute the antibody from 1:20000 to 1:40000. These recommended dilution ranges are based on the original text information and should be followed for best results.
Immunogen	The production of a human IL-2Rbeta/CD122-derived synthesized peptide is underway. We are rearranging the provided content to ensure a highly similar representation based on the information originally given. Please note that this conversation will be generated using a language model and the resulting text may differ significantly from the original content.
Properties
Concentration	1mg/ml
Purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum. The outcome of this method yielded a highly purified and refined antiserum sample.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum shelf life, it is recommended to store the product in a freezer with a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can potentially damage its quality. Therefore, it is crucial to handle the product with care to preserve its effectiveness and integrity over time.
Storage buffer	This product contains Rabbit IgG in phosphate buffered saline at a pH of 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and is guaranteed to remain stable for 12 months from the date of receipt.
Target
Background	Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Celluar localization	Plasma Membrane;
UniPort	P14784