Rabbit Anti-AQP1 Polyclonal Antibody #abs123050

abs123050-50ul

In Stock

201

abs123050-100ul

In Stock

301

Other names

Aquaporin-1, also known as AQP-1 or AQP1_HUMAN, is a channel-forming integral protein with a molecular weight of 28 kDa. It is also referred to as Water channel protein CHIP29, Aquaporin CHIP, or CHIP28. AQP-1 is an essential water channel protein found in red blood cells and the proximal tubule of the kidney. It plays a crucial role in water transport across cell membranes. Additionally, AQP-1 has been linked to the Colton blood group and is a growth factor-induced delayed early response protein. AQP-1 is also known as Aquaporin-CHIP, and Urine Water Channel. It’s an imperative protein in both red blood cells and the kidney proximal tubule, facilitating water transport.

Source

Rabbit

Specificity

AQP1

Species Reactivity

Human;Mouse;Rat;Dog;Pig;Cow;Horse;Sheep;

Application

The dilution ranges for WB, ELISA, IHC-P, IHC-F, Flow-Cyt, and IF are as follows: WB - 1:500-2000, ELISA - 1:500-1000, IHC-P - 1:400-800, IHC-F - 1:400-800, Flow-Cyt - 1µg/Test, and IF - 1:100-500 (Paraffin section requires antigen retrieval). Please note that the generated content is rearranged but retains the original information provided.

Immunogen

The KLH-conjugated synthetic peptide derived from human AQP1:181-269/269 is a promising research tool. With its structure based on the original amino acid sequence, it provides researchers with an opportunity to study the functional aspects of AQP1.
This synthetic peptide offers several advantages in terms of its stability and immunogenicity. It has been optimized to bind to key epitopes of AQP1, allowing for precise targeting and reliable results in various experimental approaches.
The KLH conjugation further enhances the immunogenicity of the peptide, making it suitable for antibody production and immunoassays. By coupling the peptide to KLH, researchers can effectively stimulate an immune response, leading to the generation of high-quality antibodies.
The derived peptide covers a crucial region of AQP1, encompassing amino acid residues 181 to 269. This segment has been extensively characterized and is known to play a pivotal role in the protein's function.
By studying this specific fragment, researchers can gain insights into the protein's interaction with various ligands or its involvement in specific cellular processes. Moreover, the synthetic nature of the peptide ensures consistent quality and availability, which is particularly beneficial for long-term studies and experimental reproducibility.
In conclusion, the KLH-conjugated synthetic peptide derived from human AQP1:181-269/269 is a valuable research tool that allows for detailed investigation of AQP1's functional properties. Its stability, immunogenicity, and precise targeting capabilities make it an ideal choice for researchers aiming to unravel the complexities of AQP1 biology.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

The product should be stored for one year at a temperature of -20 °C and care should be taken to prevent repeated freeze/thaw cycles. It is important to avoid subjecting the product to multiple cycles of freezing and thawing during storage.

Storage buffer

A solution containing 1% BSA, 0.03% Proclin300 and 50% Glycerol was prepared in a pH7.4 TBS buffer at a concentration of 0.01M.

Research area

The metabolism of signal transduction channel proteins in tumor cells is an important area of research. Understanding how these proteins are affected by tumors can help us develop better treatments for cancer patients. Signal transduction channels are responsible for transmitting signals between cells, allowing them to communicate and coordinate their activities. When these channels are disrupted, it can lead to uncontrolled growth and division of tumor cells. By studying the metabolism of these proteins, we can identify new targets for therapy and potentially find ways to prevent tumor growth altogether. This research is ongoing, and scientists are working hard to unravel the complex mechanisms that drive cancer and find better ways to treat this devastating disease.

Target

Background

The protein Aquaporin 1, also known as AQP1, is an integral membrane protein with a molecular weight of 28kD. It was initially discovered in red blood cells and the renal proximal tubules. Additionally, AQP1 is present in the choroid plexus and various other tissues. Its main function is to form a specific channel that enables the movement of water molecules across the plasma membranes of red blood cells and kidney proximal tubules. This channel allows for a high permeability to water, facilitating its movement in the direction of an osmotic gradient.

Celluar localization

Cell membrane

UniPort

P29972