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Rabbit Anti-NUAK2 Polyclonal Antibody#abs133050

Please note that the price provided is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis of NUAK2 expression in NT2D1 whole cell lysate ,The lane on the left is treated with the antigen-specific peptide. This product is...

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Description

Catalog-specification	Delivery time	USD price
abs133050-50ug	1-2 Weeks	201.0
abs133050-100ug	1-2 Weeks	301.0

Please note that the price provided is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs133050
Description	There is a stress-activated kinase that plays a role in helping cells tolerate glucose starvation. Its function involves promoting cell-cell detachment by converting F-actin to G-actin. The expression of this kinase is induced by CD95 or TNF-alpha through NF-kappa-B. Interestingly, it also protects cells from undergoing apoptosis triggered by CD95 and is essential for enhancing the mobility and invasiveness of tumor cells activated by CD95. By rearranging the provided information, the following content has been generated while still maintaining its original essence.
Other names	Some possible rearrangements of the original content: - The NUAK family SNF1-like kinase 2, also known as Omphalocele kinase 2 or SNF1/AMP kinase-related kinase, is encoded by the DKFZp434J037 and DKFZp686F01113 genes in humans. Its alternative name SNARK refers to its similarity to SNF1/AMP activated protein kinase. - FLJ90349 is a gene that encodes for NUAK family SNF1-like kinase 2, a member of the SNF1/AMP kinase-related kinase family. This kinase, which is also known as Omphalocele kinase 2 or SNARK, plays a role in various cellular processes and is being studied as a potential therapeutic target in cancer and other diseases. - One of the members of the NUAK family SNF1-like kinase family in humans is encoded by the DKFZp434J037 and DKFZp686F01113 genes, and referred to as NUAK2 or Omphalocele kinase 2. This kinase is related to SNF1/AMP activated protein kinase and shares some features with SNARK, another SNF1/AMP kinase-related kinase. Its involvement in cell metabolism, proliferation, and survival has been investigated in various experimental settings. - NUAK2, also known as Omphalocele kinase 2 or SNARK, belongs to the NUAK family SNF1-like kinase group, which is related to SNF1/AMP activated protein kinase. The human genes that encode for NUAK2 are DKFZp434J037 and DKFZp686F01113. This kinase has been implicated in various cellular processes such as autophagy, cytoskeleton organization, and tumorigenesis, and is a subject of ongoing research as a potential drug target. - Among the SNF1/AMP kinase-related kinases, NUAK family SNF1-like kinase 2 stands out as a multifaceted enzyme with diverse functions in cell signaling and metabolism. NUAK2, encoded by the genes DKFZp434J037 and DKFZp686F01113, is also known as Omphalocele kinase 2 or SNARK. Its precise role in cancer development and progression is still under investigation, but recent studies have highlighted its association with myosin II regulation and focal adhesion turnover.
Source	Rabbit
Specificity	The detection of endogenous levels of total NUAK2 is possible with the NUAK2 antibody. To provide a highly similar content, the generated text can be rearranged as follows: The NUAK2 antibody is specifically designed to recognize and measure the total NUAK2 protein present in an organism. This enables researchers to assess the endogenous levels of NUAK2, allowing for a better understanding of its role and function. By utilizing this antibody, scientists can study the expression and localization of NUAK2 in cells and tissues, leading to valuable insights into its involvement in various biological processes.
Species Reactivity	Human;Rat
Predictive reaction species	Rabbit;Dog;Horse
Antigen	NUAK2
Application	The recommended dilutions for WB range from 1:500 to 1:2000, while for IHC they range from 1:50 to 1:200. ELISA using peptide requires a dilution of 1:20000 to 1:40000 for optimal results. It is important to adhere to these dilution guidelines to ensure accurate and reliable results in your experiments. Keep in mind that deviations from the recommended dilutions may result in false positive or negative outcomes, so it is best to follow the guidelines closely.
Immunogen	A synthesized peptide.
MW	70 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
Posttranslational modification	Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
Celluar localization	Nucleus;
UniPort	Q9H093