Rabbit Anti-CXCL10 Polyclonal Antibody #abs123006

abs123006-50ul

In Stock

201

abs123006-100ul

In Stock

301

Other names

Interferon gamma-induced protein 10, also known as IFI10 or INP10, is a chemokine with a molecular weight of 10 kDa. It is part of the C-X-C motif chemokine family and is commonly referred to as CXCL10 or Crg2. This protein is induced by interferon gamma and plays a crucial role in various immune responses. Other names for this protein include C7, gamma IP10, GIP10, and Interferon-activated gene 10.
The functions of CXCL10 are mediated through interactions with its receptor, CXCR3. This chemokine is involved in the recruitment and activation of immune cells, particularly T cells, natural killer cells, and dendritic cells. It regulates the migration of these cells during inflammation and immune responses. Additionally, CXCL10 has been implicated in several diseases, including viral infections, autoimmune disorders, and cancer.
The biological significance of CXCL10 underscores the importance of understanding its mechanisms of action and regulatory pathways. Research on this protein has shed light on its role in immune surveillance, immune cell trafficking, and the balance between immune activation and tolerance. Further investigation into the molecular pathways of CXCL10 can potentially lead to the development of therapeutic interventions for various diseases.
In summary, the 10 kDa interferon gamma-induced protein, also known as CXCL10 or IFI10, is an essential chemokine involved in immune responses. It serves as a key player in immune cell migration and activation, and its dysregulation has been associated with numerous diseases. Continued research in this field promises to uncover novel insights into the functions and therapeutic potential of CXCL10.
Small inducible cytokine B10 (SCYB10), also known as gamma-IP-10, is a member of the small inducible cytokine subfamily B (Cys X Cys). The SCYB10 gene encodes a protein that plays a crucial role in immune response modulation. It functions by inducing chemotaxis and apoptosis in different cell types. The precursor form of SCYB10 is proteolytically cleaved to yield the active form. SCYB10 is involved in various inflammatory and immune-related processes, making it an important target for therapeutic interventions. Further research on SCYB10 may unravel its potential applications in the treatment of immune-mediated disorders.

Source

Rabbit

Specificity

CXCL10/IP10

Species Reactivity

Human;Mouse;Rat;

Application

ELISA can be performed at a dilution range of 1:500 to 1:1000. For immunohistochemistry on paraffin-embedded sections (IHC-P), a dilution range of 1:400 to 1:800 is recommended. Similarly, for immunohistochemistry on frozen sections (IHC-F), a dilution range of 1:400 to 1:800 is suitable. If performing immunofluorescence (IF), a dilution range of 1:100 to 1:500 can be used. It is important to note that antigen retrieval is necessary for paraffin sections in order to achieve optimal results.

Immunogen

A synthetic peptide derived from mouse CXCL10:35-98/98 has been conjugated with KLH. It is important to generate content that is highly similar to the original text by rearranging the information provided.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

It is recommended to keep the product stored at a temperature of -20 °C for a period of one year. It is important to avoid repeated instances of freezing and thawing. It is essential to follow these storage instructions to ensure the quality and potency of the product.

Storage buffer

In a pH 7.4 TBS solution containing 1% BSA, 0.03% Proclin300, and 50% glycerol, we have created a highly stable mixture. This solution is ideal for a variety of scientific applications and offers exceptional performance. It is designed to ensure that your experiments are successful, accurate, and reproducible. The glycerol present in the solution acts as a cryoprotectant, ensuring that the solution remains stable even at low temperatures. The Proclin300 is added as a preservative to prevent bacterial contamination, while the BSA acts as a stabilizer and a blocking agent. This versatile solution is a must-have in any laboratory setting.

Research area

Immunology is an essential aspect of tumor cell biology as it deals with the study of the immune response to tumors. Transcription regulators play a crucial role in controlling gene expression during this process. Their ability to manipulate the way genes are transcribed allows them to regulate important cellular functions and influence the development and behavior of tumor cells. Understanding the complex interactions between tumor cell biology, immunology, and transcription regulation is essential in developing targeted therapies and improving overall patient outcomes.

Target

Background

IP-10, or interferon-gamma-inducible 10 kD protein, is a type of CXC chemokine that is capable of attracting CD4-positive T cells while inhibiting the proliferation of normal and leukemic hemopoietic progenitors. This cytokine is produced by numerous cell types, including neutrophils, monocytes, hepatocytes, endothelial cells, and keratinocytes. Its involvement in various inflammatory pathologies, such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis, and acute anterior uveitis, has been reported. Furthermore, IL-8 and IP-10, two CXC chemokines, are believed to play a role in regulating angiogenic activity in cancer and idiopathic pulmonary fibrosis.

Celluar localization

Secreted protein

UniPort

P17515