Rabbit Anti-VEGF Polyclonal Antibody #abs119841

abs119841-50ul

In Stock

201

abs119841-100ul

In Stock

301

Other names

VEGF A, also known as vascular endothelial growth factor A, is a key player in the field of angiogenesis. This protein is encoded by the Vegf gene and is a potent mitogen for endothelial cells. VEGF A is essential for the development of blood vessels and the promotion of vascular permeability. It plays a crucial role in the growth and development of tissues and organs, including those of the heart, lungs, and brain. In addition, it is involved in a variety of pathological conditions, such as tumor growth, diabetic retinopathy, and macular degeneration. The different isoforms of VEGF A have varying roles and functions, which underscore the complexity of the angiogenic process. As such, VEGF A is a subject of active research and a therapeutic target in various diseases.

Source

Rabbit

Specificity

VEGF

Species Reactivity

Human;Mouse;

Application

The recommended dilutions for WB, ELISA, IHC-P, IHC-F, Flow-Cyt, and IF are as follows: WB dilution ranging from 1:500 to 2000, ELISA dilution ranging from 1:500 to 1000, IHC-P dilution ranging from 1:400 to 800, IHC-F dilution ranging from 1:400 to 800, Flow-Cyt dilution of 1μg/Test and IF dilution ranging from 1:100 to 500. Remember that paraffin section requires antigen retrieval. These recommended dilutions are based on the original text information and can help ensure accurate and reliable results in your experiments. Make sure to adjust the dilution based on your specific experimental conditions to achieve optimal results.

Immunogen

KLHVEGF:27-120/232。，。，。

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

It is recommended to store the product at -20 °C for a duration of one year. To maintain its quality, it is important to avoid subjecting it to repeated freeze/thaw cycles.

Storage buffer

We have a solution that contains 0.01M Tris-buffered saline with a pH of 7.4, to which we have added 1% bovine serum albumin, 0.03% Proclin300, and 50% glycerol.

Research area

Growth factors and hormones play a crucial role in the development of cancer and cardiovascular diseases. In the case of cancer, certain hormones and growth factors can stimulate the growth and division of cancer cells, leading to tumor formation. Cardiovascular diseases, on the other hand, can be influenced by imbalances in hormones and growth factors that regulate blood pressure, cholesterol levels, and blood clotting.
Diabetes, a metabolic disorder, is also closely tied to hormones. Insulin, the hormone responsible for regulating blood sugar levels, is often deficient or ineffective in individuals with diabetes. This disruption in hormone balance can lead to high blood sugar levels and, over time, damage to blood vessels, nerves, and organs.
Understanding the relationship between growth factors, hormones, and these diseases is crucial for effective treatment and prevention strategies. Researchers are continuously exploring ways to modulate hormone and growth factor levels to mitigate the risks associated with cancer, cardiovascular diseases, and diabetes. By targeting these physiological processes, it may be possible to develop more personalized and precise interventions for individuals at risk or already affected by these conditions.

Target

Background

This particular gene product is classified under the PDGF/VEGF growth factor family. It functions as a mitogen that is uniquely targeted towards endothelial cells and is responsible for a variety of effects such as inducing angiogenesis, increased vascular permeability, endothelial cell growth, cell migration, promoting vasculogenesis, and inhibition of apoptosis. The gene has numerous alternatively spliced transcript variants that result in different isoforms being formed. This is further compounded by the presence of alternate translation initiation sites that generate additional isoforms. All these facets make the gene highly versatile and adaptable in its functions. The RefSeq database provides valuable information on this gene's various variants and isoforms, making it a significant research subject for many scientists.

Celluar localization

Secreted protein

UniPort

P15692