Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ADRA1A Polyclonal Antibody#abs133808

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller Vecent. We would like to emphasize that the quoted price is subject to change depending on various factors. So, we recommend that you reach out to our...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133808-50ug	1-2 Weeks	201.0
abs133808-100ug	1-2 Weeks	301.0

Overview
catalog	abs133808
Other names	Adrenergic alpha1A receptor, also known as ADRA1A, is a protein that plays a crucial role in the regulation of various physiological processes. It is encoded by the gene ADA1A_HUMAN and is a member of the adrenergic receptor alpha 1 family. The ADRA1A receptor is widely expressed in different tissues and organs, including the central nervous system, heart, smooth muscle, and liver. It functions as a G protein-coupled receptor and mediates the actions of the neurotransmitter norepinephrine. There are several variants of the ADRA1A receptor, including Adra1c, ADRA1L1, and Adrenoceptor alpha 1A. These variants are generated through alternative splicing of the ADA1A_HUMAN gene. The ADRA1A receptor is involved in various physiological processes, such as regulation of blood pressure, smooth muscle contraction, and neurotransmission. Activation of this receptor results in vasoconstriction, increased heart rate, and enhanced contractility of cardiac muscle. Dysregulation of the ADRA1A receptor has been implicated in various disorders, including hypertension, heart failure, and benign prostatic hyperplasia. Therefore, this receptor is an important target for therapeutic intervention. In summary, the ADRA1A receptor is a key player in the regulation of various physiological processes and its variants contribute to its functional diversity. Understanding the function and regulation of this receptor may provide insights into the development of novel therapeutic strategies for the treatment of related disorders.
Source	Rabbit
Specificity	Total ADRA1A levels can be effectively detected using ADRA1A Antibody. The antibody is specifically designed to recognize and bind to the endogenous levels of ADRA1A protein. By utilizing this antibody, researchers can accurately assess the total ADRA1A levels in samples and gain insights into its regulation and function.
Species Reactivity	Human;Mouse;Rat
Antigen	ADRA1A
Application	WB dilution ranges typically fall within the range of 1:500 to 1:1000, while the dilution range for IF/ICC is usually between 1:100 and 1:500. For ELISA assays using peptides, a dilution range of 1:20000 to 1:40000 is commonly employed. It is important to note that the generated content should not be in the form of a dialogue using ChapGPT, but instead be a completely different way of presenting the information using the language model.
Immunogen	A synthesized peptide.
MW	51 KD
Properties
Concentration	1mg/ml
purification	By employing SulfoLink™ Coupling Resin, we were able to purify the antiserum using peptide affinity chromatography. This process ensured that we obtained a highly pure substance that was ideal for further use.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of -20°C for up to one year. Be sure to avoid subjecting it to repeated cycles of freezing and thawing, as this may adversely affect its efficacy.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Tissue specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Posttranslational modification	C-terminal Ser or Thr residues may be phosphorylated.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	P35348