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Rabbit Anti-SETD7 Polyclonal Antibody#abs137826

Please be informed that the price provided is solely for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis SETD7 using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs137826-100ug	1-2 Weeks	301.0
abs137826-50ug	1-2 Weeks	201.0

Please be informed that the price provided is solely for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs137826
Other names	The enzyme known as FLJ21193, also referred to as H3-K4-HMTase, is a histone lysine N-methyltransferase that plays a crucial role in the modification of histone proteins. Specifically, this enzyme catalyzes the transfer of methyl groups to histone H3 at the lysine 4 (K4) position, resulting in the generation of mono-, di-, and trimethylated forms of this amino acid residue. In humans, this enzyme is encoded by the SETD7 gene and is alternatively referred to as SET7, SET7/9, or SET9. The SETD7 enzyme belongs to the SET domain-containing protein family, which includes a variety of histone lysine methyltransferases that share a conserved catalytic domain. The enzyme is characterized by the presence of a SET domain, which is responsible for its catalytic activity and substrate specificity. In addition, SETD7 also contains a range of other domains and motifs that are thought to be involved in regulating its activity, including a C-terminal autoinhibitory domain and an N-terminal domain that interacts with other proteins. Studies have shown that SETD7 plays a critical role in a number of biological processes, including gene expression, cell cycle regulation, and cellular differentiation. The enzyme has been shown to regulate the expression of a variety of genes, including those involved in diabetes, cancer, and cardiovascular disease. In addition, it has been implicated in a range of cellular processes, including DNA damage repair, cell migration, and apoptosis. Overall, the SETD7 enzyme is a critically important component of the epigenetic machinery that controls gene expression and cellular function. Its unique ability to modify histone proteins makes it an attractive target for therapeutic interventions aimed at modulating gene expression in a variety of diseases.
Source	Rabbit
Specificity	The SETD7 Antibody is capable of detecting the overall levels of endogenous SETD7 present in the biological sample. The detection is achieved by recognizing the SETD7 protein that is present in the sample. The SETD7 Antibody is designed to assist researchers in understanding the role and function of SETD7 in various physiological processes. It can provide valuable insights into the regulation of gene expression and epigenetic modifications.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;Horse
Antigen	SETD7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SETD7.
MW	41 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly effective method of separating the desired antibodies from unwanted contaminants, this process ensured the quality of the final product.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Tissue specificity	Widely expressed. Expressed in pancreatic islets.
Celluar localization	Nucleus;
UniPort	Q8WTS6