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Rabbit Anti-BDKRB2 Polyclonal Antibody#abs137814

Description

Catalog-specification	Delivery time	USD price
abs137814-100ug	1-2 Weeks	301.0
abs137814-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137814
Other names	The B2 receptor, also known as the bradykinin receptor B2 or BK2 receptor, is a protein encoded by the BDKRB2 gene. This receptor binds with bradykinin, a peptide that regulates various physiological processes such as inflammation and blood pressure. Other names include B2BKR, B2BRA, BDKR B2, BK R2, BK-2 receptor, BK2, BK2 receptor, BKR2, and BRB2. The B2 receptor is found predominantly in smooth muscle cells and endothelial cells, and its activation leads to vasodilation and increased capillary permeability. This makes it a potential therapeutic target for hypertension and other cardiovascular diseases. Mutations in the BDKRB2 gene have been associated with various conditions such as hypertension, asthma, and migraine. The study of this receptor and its effects on the body is an active area of research, with the potential for new treatments to emerge.
Source	Rabbit
Specificity	The antibody against BDKRB2 is capable of detecting the total levels of endogenous BDKRB2. A similar statement could be formulated by rephrasing the original text, while remaining faithful to the information presented.
Species Reactivity	Human
Antigen	BDKRB2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human BDKRB2.
MW	78 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	One-year storage of the item should be done at a temperature of -20 °C. It is important to prevent subjecting the item to multiple freeze/thaw cycles.
Storage buffer	This product contains rabbit IgG suspended in a solution of phosphate-buffered saline with pH 7.4, 150mM NaCl, and 0.02% sodium azide, and is supplemented with 50% glycerol for storage. It is recommended that the product be stored at -20°C and has a shelf life of 12 months from the date of receipt.
Target
Background	Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Tissue specificity	Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
Celluar localization	Endosome;Plasma Membrane;
UniPort	P30411