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Rabbit Anti-ERAP1 Polyclonal Antibody#abs137824

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Description

Catalog-specification	Delivery time	USD price
abs137824-100ug	1-2 Weeks	301.0
abs137824-50ug	1-2 Weeks	201.0

Overview
catalog	abs137824
Other names	The protein known as Adipocyte-derived leucine aminopeptidase, or A-LAP, is also referred to as ALAP, Aminopeptidase PILS, ARTS-1, and ERAAP1. It is associated with the endoplasmic reticulum and plays a role in antigen processing. Another name for it is Puromycin-insensitive leucyl-specific aminopeptidase. Additionally, it is involved in regulating the shedding of type 1 tumor necrosis factor receptors. It is sometimes referred to as VEGF-induced aminopeptidase.
Source	Rabbit
Specificity	The ERAP1 Antibody is capable of detecting the overall amount of ERAP1 present in the organism naturally. The detection is made with the use of the antibody which is able to identify the endogenous levels of ERAP1. By detecting the total amount, it is possible to monitor any changes in the levels of this protein. This information can prove useful in understanding the role of ERAP1 in various physiological processes.
Species Reactivity	Human
Predictive reaction species	Dog
Antigen	ERAP1
Application	WB: The working dilution for Western blotting is recommended to be 1:1000-3000. IF/ICC: For immunofluorescence or immunocytochemistry, the suggested dilution is 1:100-1:500. ELISA(peptide): If you are planning to perform ELISA using a peptide, it is advisable to use a dilution range of 1:20000-1:40000.
Immunogen	A synthesized peptide derived from human ERAP1.
MW	107 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Tissue specificity	Ubiquitous.
Posttranslational modification	N-glycosylated.
Celluar localization	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	Q9NZ08