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Rabbit Anti-UBE2A/B Polyclonal Antibody#abs139519

Description

Catalog-specification	Delivery time	USD price
abs139519-100ug	1-2 Weeks	301.0
abs139519-50ug	1-2 Weeks	201.0

Please note that the price stated above is for your reference only. For detailed pricing information, please get in touch with our sales representative Vecent. We would like to inform you that the price mentioned above is not final and is subject to change depending on various factors. Therefore, we highly recommend you to contact our sales representative Vecent for more information about the pricing. Thank you!

Overview
catalog	abs139519
Other names	The E2 17kDa protein, also known as the RAD6 homolog, plays an essential role in the ubiquitin-proteasome system. It is an important member of the ubiquitin-conjugating enzyme family and participates in protein degradation pathways. The E2 17kDa protein is encoded by two genes, UBE2A and UBE2B, which show some functional overlap but also have distinct roles. UBE2A is also known as RAD6 homolog A and is involved in DNA repair and the cell cycle. UBE2B, on the other hand, is also known as RAD6 homolog B and is required for the maintenance of genome stability. Both proteins are highly conserved and exist in a variety of organisms, from yeast to humans. The E2 17kDa is a crucial component of the ubiquitin-proteasome system, which is responsible for the selective degradation of proteins that have been tagged with ubiquitin. Through its catalytic activity, the E2 17kDa protein assists in the transfer of ubiquitin to target proteins, thereby signaling their degradation. Dysfunction or dysregulation of the E2 17kDa protein can lead to the development of various diseases, including cancer and neurodegenerative diseases.
Source	Rabbit
Specificity	Total UBE2A/B endogenous levels are detected by the UBE2A/B Antibody. To create new content based on the original text information, it is important to ensure that the rearranged content reflects the meaning accurately and maintains the context. Rearranging the statement, we can say: The UBE2A/B Antibody is used to measure the endogenous levels of total UBE2A/B present in a sample.
Species Reactivity	Human;Mouse;Rat
Antigen	UBE2A/B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human UBE2A/B.
MW	17 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography. Let's generate a highly similar content by rearranging the provided information while maintaining the original context. However, please note that the generated content might differ significantly from the original text due to the nature of language models.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	P63146/P49459