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Rabbit Anti-ANAPC13 Polyclonal Antibody#abs132750

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Description

Catalog-specification	Delivery time	USD price
abs132750-100ug	1-2 Weeks	301.0
abs132750-50ug	1-2 Weeks	201.0

Overview
catalog	abs132750
Description	The anaphase promoting complex/cyclosome (APC/C) is a crucial component involved in regulating the cell cycle. Acting as a cell cycle-regulated E3 ubiquitin ligase, it exerts control over mitosis and the G1 phase of the cell cycle. By mediating the process of ubiquitination and subsequent degradation of specific target proteins, the APC/C complex plays a vital role in driving progression through different cell cycle stages. Its primary function lies in mediating the formation of 'Lys-11'-linked polyubiquitin chains, while also playing a lesser role in facilitating the formation of 'Lys-48' and 'Lys-63'-linked polyubiquitin chains.
Other names	APC13, also known as Anaphase-promoting complex subunit 13 or Cyclosome subunit 13, is a crucial member of the Anaphase-Promoting Complex (APC) family. It is responsible for the activation and targeting of various substrates for ubiquitination during the cell cycle, ensuring proper progression and division. APC13 interacts with various proteins within the APC, contributing to its overall function in controlling cell cycle checkpoints. It is also involved in the regulation of DNA damage response and mitotic spindle assembly. Mutations in the APC13 gene can lead to abnormal cell division and contribute to the development of cancer.
Source	Rabbit
Specificity	The ANAPC13 antibody is capable of identifying total ANAPC13 proteins at levels that naturally occur within the body. This means that it can accurately detect ANAPC13 proteins without the need for artificial enhancement or amplification.
Species Reactivity	Human;Mouse
Antigen	ANAPC13
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	8 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed in purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a period of one year. It is important to note that freezing and thawing should be avoided as much as possible if you want to keep the product intact. Therefore, it is recommended to store it in a cold environment and try to minimize any temperature changes that might occur. These simple measures can help you preserve your product for longer and ensure that it continues to meet your needs over time.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Celluar localization	Nucleus;
UniPort	Q9BS18